Gamithromycin

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Gamithromycin
Clinical data
Trade namesZactran
Other namesML-1709460, ML-460
License data
Routes of
administration		Subcutaneous
Drug classMacrolide antibiotic
ATCvet code
Legal status
Legal status
Identifiers
  • (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,8,10,12,14-hexamethyl-7-propyl-1-oxa-7-azacyclopentadecan-15-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.123.704 Edit this at Wikidata
Chemical and physical data
FormulaC40H76N2O12
Molar mass777.050 g·mol−1
3D model (JSmol)
  • [H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)N(CCC)C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C
  • InChI=1S/C40H76N2O12/c1-15-17-42-21-22(3)33(44)40(11,48)29(16-2)52-36(46)26(7)32(53-30-20-39(10,49-14)34(45)27(8)51-30)25(6)35(38(9,47)19-23(42)4)54-37-31(43)28(41(12)13)18-24(5)50-37/h22-35,37,43-45,47-48H,15-21H2,1-14H3/t22-,23+,24+,25-,26+,27-,28-,29+,30-,31+,32-,33+,34-,35+,37-,38+,39+,40+/m0/s1
  • Key:VWAMTBXLZPEDQO-UZSBJOJWSA-N

Gamithromycin, sold under the brand name Zactran, is a veterinary medication used for the treatment of cattle, pigs, and sheep.[3][4][5] It is a macrolide antibacterial.[3][4] It is a 7a-azalide.[6]

It was approved for veterinary use in the European Union in 2008.[3][4]

Veterinary uses

In the EU, gamithromycin is indicated for the treatment and prevention of bovine respiratory disease in cattle, swine respiratory disease in pigs, and infectious pododermatitis (foot rot) in sheep.[3][4][6]

In the US, gamithromycin is indicated for the treatment of bovine respiratory disease in cattle.[1]

References

  1. ^ a b "Zactran - gamithromycin injection, solution". DailyMed. 17 April 2024. Retrieved 29 June 2024.
  2. ^ "Zactran". U.S. Food and Drug Administration (FDA). Retrieved 29 June 2024.
  3. ^ a b c d e "Zactran EPAR". European Medicines Agency. 1 August 2008. Retrieved 29 June 2024.
  4. ^ a b c d e "Zactran PI". Union Register of veterinary medicinal products. 28 July 2008. Retrieved 29 June 2024.
  5. ^ Budde JA, McCluskey DM (2023). "Gamithromycin". Plumb's Veterinary Drug Handbook (10th ed.). Tulsa, OK: Educational Concepts, LLC, dba VetMedux. p. 571. ISBN 978-1-394-17220-7.
  6. ^ a b "Gamithromycin". Inxight Drugs. Retrieved 29 June 2024. Public Domain This article incorporates text from this source, which is in the public domain.

External links


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