Denaverine
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AHFS/Drugs.com | International Drug Names |
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Routes of administration | intramuscular injection, suppositories |
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Pharmacokinetic data | |
Bioavailability | 8% (suppositories), 37% (oral solution) |
Metabolism | mainly hepatic, at least 11 metabolites |
Elimination half-life | 34 hours |
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Chemical and physical data | |
Formula | C24H33NO3 |
Molar mass | 383.532 g·mol−1 |
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Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during parturition.[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.[2]
Mechanism of action
Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.[3]
References
- ^ Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
- ^ Dootz H, Kuhlmann A, Hoffmann K, eds. (2005). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.
- ^ Dinnendahl V, Fricke U, eds. (2010). Arzneistoff-Profile (in German). Vol. 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.
Categories:
- CS1 German-language sources (de)
- Articles with short description
- Short description matches Wikidata
- Drugs with non-standard legal status
- Articles with changed ChemSpider identifier
- Articles with changed EBI identifier
- Articles with changed InChI identifier
- Chemical pages without DrugBank identifier
- Drugboxes which contain changes to verified fields
- Drugboxes which contain changes to watched fields
- Antispasmodics
- Dimethylamino compounds
- Carboxylate esters
- Ethers
- All stub articles
- Genito-urinary system drug stubs