Proto-oncogene Wnt-1

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WNT1
Identifiers
AliasesWNT1, BMND16, INT1, OI15, Wnt family member 1
External IDsOMIM: 164820 MGI: 98953 HomoloGene: 3963 GeneCards: WNT1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005430

NM_021279

RefSeq (protein)

NP_005421

NP_067254

Location (UCSC)Chr 12: 48.98 – 48.98 MbChr 15: 98.69 – 98.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 (INT1) gene.[5][6]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125084 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022997 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ van Ooyen A, Kwee V, Nusse R (Jan 1986). "The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences". EMBO J. 4 (11): 2905–9. doi:10.1002/j.1460-2075.1985.tb04021.x. PMC 554596. PMID 2998762.
  6. ^ Arheden K, Mandahl N, Strombeck B, Isaksson M, Mitelman F (May 1988). "Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization". Cytogenet Cell Genet. 47 (1–2): 86–87. doi:10.1159/000132513. PMID 3281802.
  7. ^ "Entrez Gene: WNT1 wingless-type MMTV integration site family, member 1".

Further reading