Villoglandular adenocarcinoma of the cervix

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Villoglandular adenocarcinoma of the cervix
Other names: Villoglandular papillary adenocarcinoma, papillary villoglandular adenocarcinoma, well-differentiated villoglandular adenocarcinoma (VGA)
Liquid-based cytology features of case (Villoglandular adenocarcinoma of the cervix)
SpecialtyPathology, gynecology

Villoglandular adenocarcinoma of the cervix is a rare type of cervical cancer that, in relation to other cervical cancers, is typically found in younger women and has a better prognosis.[1]

A similar lesion, villoglandular adenocarcinoma of the endometrium, may arise from the inner lining of the uterus, the endometrium.[2]

Signs and symptoms

The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.[citation needed]


In terms of the etiology of Villoglandular adenocarcinoma of the cervix, one finds that the exact cause of the condition is not understood, but it is associated with human papillomavirus[3][4]


The diagnosis is based on tissue examination, e.g. biopsy.

The name of the lesion describes it microscopic appearance. It has nipple-like structures with fibrovascular cores (papillae) that are long in relation to their width (villus-like), which are covered with a glandular pseudostratified columnar epithelium.[citation needed]


The treatment is dependent on the stage. As the prognosis of this tumour is usually good, fertility sparing approaches (conization, cervicectomy) may be viable treatment options.[citation needed]

See also


  1. Korach, J.; Machtinger, R.; Perri, T.; Vicus, D.; Segal, J.; Fridman, E.; Ben-Baruch, G. (2009). "Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge". Acta Obstet Gynecol Scand. 88 (3): 355–8. doi:10.1080/00016340902730359. PMID 19172445. S2CID 5835426.
  2. Zaino, RJ.; Kurman, RJ.; Brunetto, VL.; Morrow, CP.; Bentley, RC.; Cappellari, JO.; Bitterman, P. (Nov 1998). "Villoglandular adenocarcinoma of the endometrium: a clinicopathologic study of 61 cases: a gynecologic oncology group study". Am J Surg Pathol. 22 (11): 1379–85. doi:10.1097/00000478-199811000-00008. PMID 9808130.
  3. Chen, Jia-Hua; Duan, Hui; Yu, Xiao-Bo; Zhao, Hong-Wei; Chen, Xu; Li, Pengfei; Li, Zhi-Qiang; Li, Bing-Xin; Pan, Lu-Yao; Yan, Xiaojian; Chen, Chunlin (1 April 2021). "Clinical features and prognostic factors of cervical villoglandular adenocarcinoma". International Journal of Gynecologic Cancer. 31 (4). doi:10.1136/ijgc-2020-002044. ISSN 1048-891X. Archived from the original on 8 February 2023. Retrieved 11 November 2023.
  4. Dietl, Anna K.; Beckmann, Matthias W.; Aumann, Konrad (2021). "Villoglandular adenocarcinoma of the uterine cervix: a systematic review and meta-analysis". Archives of Gynecology and Obstetrics. 304 (2): 317–327. doi:10.1007/s00404-021-06077-9. ISSN 0932-0067. Archived from the original on 2023-11-13. Retrieved 2023-11-11.