Video:Trichuriasis

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Description

Trichuriasis is an infection by the parasitic worm Trichuris trichiura (whipworm).[1] If infection is only with a few worms, there are often no symptoms.[2] In those who are infected with many worms, there may be abdominal pain, tiredness and diarrhea.[2] The diarrhea sometimes contains blood.[2] Infections in children may cause poor intellectual and physical development.[2] Low red blood cell levels may occur due to loss of blood.[1]The highest clearance rates are obtained by combining mebendazole or albendazole with ivermectin. [3][4]

Presentation

Physical growth delay, weight loss, nutritional deficiencies, and anemia (due to long-standing blood loss) are characteristic of infection, and these symptoms are more prevalent and severe in children than adults.[5][6]

Cause

Trichuriasis is caused by a parasitic worm also known as a helminth called Trichuris trichiura. It belongs to the genus Trichuris, formerly known as Trichocephalus, meaning hair head, which would be a more accurate name; however the generic name is now Trichuris, which means hair tail. Infections by parasitic worms are known as helminthiasis.[7][8]

Transmission

Humans can become infected with the parasite due to ingestion of infective eggs by mouth contact with hands or food contaminated with egg-carrying soil. However, there have also been rare reported cases of transmission of T. trichiura by sexual contact. Some major outbreaks have been traced to contaminated vegetables (due to presumed soil contamination).[7][9]

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Mechanism

Unembryonated eggs are passed in the feces of a previous host to the soil. In the soil, these eggs develop into a 2-cell stage and then into an advanced cleavage stage. Once at this stage, the eggs embryonate and then become infective, a process that occurs within a month. Next, the infective eggs are ingested by way of soil-contaminated hands or food and hatch inside the small intestine, releasing larvae into the gastrointestinal tract. These larvae burrow into a villus and develop into adults . They then migrate into the cecum and ascending colon where they thread their anterior portion into the tissue mucosa and reside permanently for their year-long lifespan. [10][11]

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Diagnosis

A stool ova and parasites exam reveals the presence of typical whipworm eggs. Typically, the Kato-Katz thick-smear technique is used for identification of the Trichuris trichiura eggs in the stool sample.Although colonoscopy is not typically used for diagnosis, as the adult worms can be overlooked, especially with imperfect colon, there have been reported cases in which colonoscopy has revealed adult worms. Colonoscopy can directly diagnose trichuriasis by identification of the threadlike form of worms with an attenuated, whip-like end.[12][13][7][14]

References

  1. 1.0 1.1 "Parasites - Trichuriasis (also known as Whipworm Infection)". CDC. January 10, 2013. Archived from the original on 1 March 2014. Retrieved 5 March 2014.
  2. 2.0 2.1 2.2 2.3 "Soil-transmitted helminth infections Fact sheet N°366". World Health Organization. June 2013. Archived from the original on 21 February 2014. Retrieved 5 March 2014.
  3. Knopp S, Mohammed KA, Speich B, et al. (2010). "Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial". Clin Infect Dis. 51 (12): 1420–8. doi:10.1086/657310. PMID 21062129. (Knopp S, Mohammed KA, Speich B, Hattendorf J, Khamis IS, Khamis AN, Stothard JR, Rollinson D, Marti H, Utzinger J ).
  4. Adegnika, Ayola Akim; Lötsch, Felix; Mba, Regis Maurin Obiang; Ramharter, Michael (1 December 2015). "Update on Treatment and Resistance of Human Trichuriasis". Current Tropical Medicine Reports. 2 (4): 218–223. doi:10.1007/s40475-015-0061-z. ISSN 2196-3045. Archived from the original on 14 October 2022. Retrieved 18 May 2024.
  5. Aponte-Pieras, J; Mesgun, S; Hong, A; Farooqui, T; Elmofti, Y; Lankarani, D; Aziz, H; Ono, J; Saud, B (July 2022). "Symptomatic Anemia Due to Trichuriasis". ACG case reports journal. 9 (7): e00826. doi:10.14309/crj.0000000000000826. PMID 35822157. Archived from the original on 2022-08-02. Retrieved 2024-05-19.
  6. Caldrer, Sara; Ursini, Tamara; Santucci, Beatrice; Motta, Leonardo; Angheben, Andrea (13 May 2022). "Soil-Transmitted Helminths and Anaemia: A Neglected Association Outside the Tropics". Microorganisms. 10 (5): 1027. doi:10.3390/microorganisms10051027. Archived from the original on 3 June 2024. Retrieved 2 June 2024.
  7. 7.0 7.1 7.2 Viswanath, Avinash; Yarrarapu, Siva Naga S.; Williams, Mollie (2024). "Trichuris trichiura Infection". StatPearls. StatPearls Publishing. Archived from the original on 2024-05-15. Retrieved 2024-05-14.
  8. "Pathogen Safety Data Sheets: Infectious Substances – Trichuris trichiura". www.canada.ca. 7 January 2011. Archived from the original on 6 June 2023. Retrieved 26 May 2024.
  9. Betson, Martha; Søe, Martin Jensen; Nejsum, Peter (1 December 2015). "Human Trichuriasis: Whipworm Genetics, Phylogeny, Transmission and Future Research Directions". Current Tropical Medicine Reports. 2 (4): 209–217. doi:10.1007/s40475-015-0062-y. ISSN 2196-3045. Archived from the original on 21 January 2022. Retrieved 3 June 2024.
  10. "Image:Trichuris trichiura Life Cycle". MSD Manual Professional Edition. Archived from the original on 2024-05-26. Retrieved 2024-05-25.
  11. "Trichuris Trichiura (Whipworm) Infection (Trichuriasis): Background, Pathophysiology, Epidemiology". Medscape. 18 August 2023. Archived from the original on 12 February 2024. Retrieved 2 June 2024.
  12. Ok, KS; Kim, YS; Song, JH; Lee, JH; Ryu, SH; Lee, JH; Moon, JS; Whang, DH; Lee, HK (September 2009). "Trichuris trichiura infection diagnosed by colonoscopy: case reports and review of literature". The Korean journal of parasitology. 47 (3): 275–80. doi:10.3347/kjp.2009.47.3.275. PMID 19724702. Archived from the original on 2024-05-19. Retrieved 2024-05-17.
  13. Barda, Beatrice Divina; Keiser, Jennifer; Albonico, Marco (1 December 2015). "Human Trichuriasis: Diagnostics Update". Current Tropical Medicine Reports. 2 (4): 201–208. doi:10.1007/s40475-015-0063-x. ISSN 2196-3045. Archived from the original on 11 June 2018. Retrieved 18 May 2024.
  14. "Trichuriasis - Trichuriasis". MSD Manual Professional Edition. Retrieved 4 October 2024.