Ugly duckling sign

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Ugly duckling sign
Seborrheic keratosis associated with dysplastic nevus.png
A spot that looks the odd one out

The ugly duckling sign is a medical sign used in dermatology to identify a potential skin cancer by looking for an odd looking spot; one that is different to others in the same individual.[1][2]

It was based on the observation that most moles on a person are somewhat similar, so that should one appear out of place, melanoma may be suspected.[3][4]

It was introduced by J. J. Grob and J. J. Bonerandi in 1998.[5]

See also


  1. Gaudy-Marqueste, Caroline; Wazaefi, Yanal; Bruneu, Yvane; Triller, Raoul; Thomas, Luc; Pellacani, Giovanni; Malvehy, Josep; Avril, Marie-Françoise; Monestier, Sandrine; Richard, Marie-Aleth; Fertil, Bernard; Grob, Jean-Jacques (1 April 2017). "Ugly Duckling Sign as a Major Factor of Efficiency in Melanoma Detection". JAMA Dermatology. 153 (4): 279–284. doi:10.1001/jamadermatol.2016.5500. ISSN 2168-6068. Archived from the original on 29 March 2023. Retrieved 9 August 2023.
  2. Daniel Jensen, J; Elewski, BE (February 2015). "The ABCDEF Rule: Combining the "ABCDE Rule" and the "Ugly Duckling Sign" in an Effort to Improve Patient Self-Screening Examinations". The Journal of clinical and aesthetic dermatology. 8 (2): 15. PMID 25741397. Archived from the original on 2023-04-17. Retrieved 2023-08-09.
  3. Yu, Zhen; Mar, Victoria; Ericksson, Anders; Chandra, Shakes; Bonnington, Paul; Zhang, Lei; Ge, Zongyuan (2021). "End to end ugly duckling sign for melanoma identification and transformers". In Bruijne, Marleen de; Cattin, Philippe C.; Cotin, Stéphane; Padoy, Nicolas; Speidel, Stefanie; Zheng, Yefeng; Essert, Caroline (eds.). Medical Image Computing and Computer Assisted Intervention – MICCAI 2021: 24th International Conference, Strasbourg, France, September 27 – October 1, 2021, Proceedings, Part VII. Springer. pp. 176–184. ISBN 978-3-030-87234-2. Archived from the original on August 11, 2023. Retrieved August 9, 2023.
  4. Welzel, Julia; Winkler, Julia K.; Hansler, Holger A.; Junger, Michael; Kiani, Charlotte; Braun, Stefan A.; Whittbecker, Linda M.; Glaser, Regine; Zink, Alexander (2023). "28. Digital dermatology". In Huss, Ralf (ed.). Digital Medicine: Bringing Digital Solutions to Medical Practice. Singapore: CRC Press. p. 457-458. ISBN 978-1-000-86897-5. Archived from the original on 2023-08-11. Retrieved 2023-08-09.
  5. Del Marmol, Veronique; Baitalle, Veronique; Trakatelli, Myrto-Georgia; Ulrich, Claas (2010). "12. Skin cancer prevention". In Stockfleth, Eggert; Rosen, Ted; Schumaak, Steven (eds.). Managing Skin Cancer. Heidelberg: Springer. p. 217. ISBN 978-3-540-79347-2. Archived from the original on 2023-07-30. Retrieved 2023-08-09.

Further reading