UDP-2,3-diacylglucosamine diphosphatase

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UDP-2,3-diacylglucosamine diphosphatase
Identifiers
EC no.3.6.1.54
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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UDP-2,3-diacylglucosamine diphosphatase (EC 3.6.1.54, UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine pyrophosphatase, ybbF (gene), lpxH (gene)) is an enzyme with systematic name UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate phosphohydrolase.[1][2] This enzyme catalyses the following chemical reaction

UDP-2,3-bis[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H2O 2,3-bis[(3R)-3-hydroxymyristoyl]-beta-D-glucosaminyl 1-phosphate + UMP

The enzyme catalyses a step in the biosynthesis of lipid A.

References

  1. ^ Babinski KJ, Ribeiro AA, Raetz CR (July 2002). "The Escherichia coli gene encoding the UDP-2,3-diacylglucosamine pyrophosphatase of lipid A biosynthesis". The Journal of Biological Chemistry. 277 (29): 25937–46. doi:10.1074/jbc.m204067200. PMID 12000770.
  2. ^ Babinski KJ, Kanjilal SJ, Raetz CR (July 2002). "Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene". The Journal of Biological Chemistry. 277 (29): 25947–56. doi:10.1074/jbc.m204068200. PMID 12000771.

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