Tyloxapol
Clinical data | |
---|---|
AHFS/Drugs.com | International Drug Names |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider |
|
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.209.660 |
Chemical and physical data | |
Formula | (C15H21O(C2H4O)m)n |
Molar mass | variable |
(what is this?) (verify) |
Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent[citation needed] (containing mucus and pus) bronchopulmonary secretions,[1][2] administered by inhalation through a nebulizer[3] or with a stream of oxygen.
With intraperitoneal injection, tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. This mechanism is used to induce experimental hyperlipidemia in animals.[4]
Tyloxapol is the main active ingredient of the medical device Tacholiquin. Tacholiquin is an expectorant designated for inhalation and instillation reaching the upper and lower airways. Other brand names of pharmaceutical products containing Tyloxapol are Exosurf and Alevaire.
References
- ^ Sehgal SS, Ewing CK, Richards T, Taeusch HW (January 1994). "Modified bovine surfactant (Survanta) versus a protein-free surfactant (Exosurf) in the treatment of respiratory distress syndrome in preterm infants: a pilot study". Journal of the National Medical Association. 86 (1): 46–52. PMC 2607653. PMID 8151722.
- ^ Rubin BK, Ramirez O, King M (April 1992). "Mucus rheology and transport in neonatal respiratory distress syndrome and the effect of surfactant therapy". Chest. 101 (4): 1080–5. doi:10.1378/chest.101.4.1080. PMID 1555424.
- ^ "Tyloxapol definition". Drugs.com.
- ^ Kourounakis AP, Victoratos P, Peroulis N, Stefanou N, Yiangou M, Hadjipetrou L, Kourounakis PN (October 2002). "Experimental hyperlipidemia and the effect of NSAIDs". Experimental and Molecular Pathology. 73 (2): 135–8. doi:10.1006/exmp.2002.2449. PMID 12231215.
- Articles with short description
- Short description matches Wikidata
- Articles with changed DrugBank identifier
- Chemicals that do not have a ChemSpider ID assigned
- Articles with changed KEGG identifier
- Articles with changed EBI identifier
- ECHA InfoCard ID from Wikidata
- Infobox-drug molecular-weight unexpected-character
- Articles without InChI source
- Drugs with no legal status
- Drugboxes which contain changes to verified fields
- Drugboxes which contain changes to watched fields
- All articles with unsourced statements
- Articles with unsourced statements from December 2013
- Expectorants
- Phenol ethers
- All stub articles
- Respiratory system drug stubs