|Side effects||Itchiness, irritation, easy sunburns|
|Chemical and physical data|
|Molar mass||459.586 g·mol−1|
|3D model (JSmol)|
Common side effects include itchiness, irritation, and easy sunburns. There are concerns that use during pregnancy may harm the baby. It is a retinoid; specifically a fourth generation selective retinoic acid receptor (RAR)-γ agonist.
Trifarotene is used in the United States for the treatment of acne in people nine years of age and older.
It is used by applying it to the skin once per day at a dose of 0.005%.
Society and culture
It was granted orphan drug designation for the treatment of congenital ichthyosis by both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA). In December 2019, its labelling and package leaflet text received a decentralised approval for 16 European countries. The current approval status in each of these 16 countries is unknown.
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- "Trifarotene Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). 24 December 1999. Retrieved 19 August 2020.
- "EU/3/20/2264". European Medicines Agency (EMA). 12 August 2020. Retrieved 19 August 2020.
- "Galderma receives a positive outcome through the European Decentralised Procedure for AKLIEF (trifarotene 50 mcg/g cream), the first new retinoid molecule for acne in the European Union in 25 years". Businesswire. 20 December 2019.