|Trade names||Fasigyn, Simplotan, Tindamax, others|
|Main uses||Bacterial vaginosis, amoebiasis, giardiasis, trichomoniasis|
|Side effects||Upset stomach, brownish urine, headache, allergic reaction|
|Typical dose||2 gm once daily|
|Elimination half-life||12–14 hours|
|Excretion||Urine (20–25%), faeces (12%)|
|Chemical and physical data|
|Molar mass||247.27 g·mol−1|
|3D model (JSmol)|
Tinidazole, sold under the brand name Tindamax among others, is a medication used to treat a number of infections including amebiasis, giardiasis, trichomoniasis, bacterial vaginosis, and nongonococcal urethritis. It is taken by mouth.
Common side effects include nausea, tiredness, and headaches. Other side effects may include brownish urine, peripheral neuropathy, and allergic reactions. Use is not recommended during the initial part of pregnancy. It is a member of the nitroimidazole class and is believed to work by affecting DNA.
Tinidazole was developed in 1969. It is available as a generic medication. In the United Kingdom 16 tablets of 500 mg costs the NHS about £11 as of 2021. This amount in the United States costs about 35 USD.
Tinidazole is used for infections from amoebae, giardia, and trichomonas, just like metronidazole. Tinidazole may be a therapeutic alternative in the setting of metronidazole intolerance. Tinidazole may also be used to treat a variety of other bacterial infections (e.g., as part of combination therapy for Helicobacter pylori eradication protocols).
The dose in adults is typically 2 grams once per day; while in children 50 mg/kg is used. For amoebiasis 3 days is used if the intestines are affected and 5 days if the liver is affected. For giardiasis, trichomoniasis, and bacterial vaginosis a single dose is used.
Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.
Society and culture
Tinidazole is marketed by Mission Pharmacal under the brand name Tindamax, by Pfizer under the names Fasigyn and Simplotan, and in some Asian countries as Sporinex.
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- BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 574. ISBN 978-0-85711-369-6.CS1 maint: date format (link)
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