Timelotem

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Timelotem
Clinical data
ATC code
  • none
Identifiers
  • 10-fluoro-3-methyl-7-thiophen-2-yl-2,4,4a,5-tetrahydro-1H-pyrazino[1,2-a][1,4]benzodiazepine
CAS Number
PubChem CID
Chemical and physical data
FormulaC17H18FN3S
Molar mass315.41 g·mol−1
3D model (JSmol)
  • CN1CCN2C(C1)CN=C(C3=C2C=C(C=C3)F)C4=CC=CS4
  • InChI=1S/C17H18FN3S/c1-20-6-7-21-13(11-20)10-19-17(16-3-2-8-22-16)14-5-4-12(18)9-15(14)21/h2-5,8-9,13H,6-7,10-11H2,1H3
  • Key:ICHHTOMWWAMJQP-UHFFFAOYSA-N

Timelotem is a benzodiazepine derivative with an unusual activity profile. Unlike most benzodiazepines, timelotem has little or no activity at the GABAA receptor, but instead acts as an atypical antipsychotic drug with similar pharmacology and effects to the structurally related drug clozapine.[1] It has two enantiomers, but has only been studied as the racemic mix.

See also

References

  1. ^ Schmidt WJ, Krähling H, Ruhland M (October 1987). "Antagonism of AP-5- and amphetamine-induced behaviour by timelotem as compared with clozapine and haloperidol". Life Sciences. 41 (16): 1909–14. doi:10.1016/0024-3205(87)90742-9. PMID 2889124.
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