Thienotriazolodiazepine

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Core structure of thienotriazolodiazepines

A thienotriazolodiazepine[1] is a heterocyclic compound containing a diazepine ring fused to thiophene and triazole rings. Thienotriazolodiazepine forms the central core of several pharmaceutical drugs including:

Thienotriazolodiazepines interact with the benzodiazepine receptor site, they typically have similar effects as 1,4-benzodiazepines (such as diazepam) and triazolobenzodiazepines (such as alprazolam).

Thienotriazolodiazepines that are not GABAA receptor positive allosteric modulators include:

References

  1. ^ Catabay, A.; Taniguchi, M.; Jinno, K.; Pesek, J. J.; Williamsen, E. (1 March 1998). "Separation of 1,4-Benzodiazepines and Analogues Using Cholesteryl-10-Undecenoate Bonded Phase in Microcolumn Liquid Chromatography". Journal of Chromatographic Science. 36 (3): 113. doi:10.1093/chromsci/36.3.111.
  2. ^ Hirota, N; Yasuda, D; Hashidate, T; Yamamoto, T; Yamaguchi, S; Nagamune, T; Nagase, T; Shimizu, T; Nakamura, M (Feb 2010). "Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor". Journal of Biological Chemistry. 285 (8): 5931–40. doi:10.1074/jbc.M109.066282. PMC 2820818. PMID 20007715.{{cite journal}}: CS1 maint: unflagged free DOI (link)