Terizidone

Terizidone
Names
Other names	4-[({4-[N-(3-oxo-1,2-oxazolidin-4-yl)carboximidoyl]phenyl}methylidene)amino]-1,2-oxazolidin-3-one
	IUPAC name 4,4'-{1,4-Phenylenebis[(E)methylylidene; (E)azanylylidene]}bis(1,2-oxazolidin-3-one);
Clinical data
Main uses	Tuberculosis
Side effects	Seizures, slurred speech, trouble sleeping, confusion, depression
Pregnancy; category	C;
External links
AHFS/Drugs.com	International Drug Names
Chemical and physical data
Formula	C14H14N4O4
Molar mass	302.290 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3NOCC3/N=C/c2ccc(/C=N/C1C(=O)NOC1)cc2;
	InChI InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)/b15-5+,16-6+ ; Key:ODKYYBOHSVLGNU-IAGONARPSA-N ;

Terizidone (Trd) is an antibiotic used to treat tuberculosis.^[1] Specifically it is used in multi-drug-resistant tuberculosis (MDR-TB) when other agents are not suitable.^[1] It is used together with other tuberculosis medication and vitamin B6.^[2] It is generally take by mouth for about 2 years.^[2]

Side effects may include seizures, slurred speech, trouble sleeping, confusion, and depression.^[1] Side effects are believed to be less than the similar medication cycloserine.^[1] It should not be used in those with significant kidney problems.^[2] It works by stoping bacterial growth after being broken down into cycloserine.^[1]^[3]

The medication may be available from the Stop TB Partnership.^[4] It is not available in the United States.^[1] It is on the World Health Organization's List of Essential Medicines as an alternative to cycloserine.^[5] As of 2015, 50 tablets of 250 mg costs about 80 USD.^[4]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Ramanathan, Meenakshi R. (2019). "Chapter 28 - Drugs in tuberculosis and leprosy". Side Effects of Drugs Annual. Elsevire. pp. 321–338. Archived from the original on 8 May 2023. Retrieved 12 September 2023.
↑ ^2.0 ^2.1 ^2.2 "TERIZIDON, 250 mg, capsules, hard" (PDF). Archived (PDF) from the original on 13 September 2023. Retrieved 12 September 2023.
↑ Abraham, Donald J. (2021). Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set. John Wiley & Sons. ISBN 9781119530305. Archived from the original on 2023-09-13. Retrieved 2023-09-12.
↑ ^4.0 ^4.1 The Selection and Use of Essential Medicines: Report of the WHO Expert Committee, 2015. WHO. 2015. p. 34. ISBN 9789241209946. Archived from the original on 13 September 2023. Retrieved 12 September 2023.
↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.

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