Template:Side effects of estramustine phosphate (FDA)
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References
- ^ "Emcyt estramustine phosphate sodium capsules" (PDF). FDA. Retrieved 14 March 2022.
| Side effect | Estramustine phosphate (oral 11.5–15.9 mg/kg/day) (n = 93) (%) |
Diethylstilbestrol (oral 3.0 mg/day) (n = 93) (%) |
|---|---|---|
| Cardiovascular and respiratory | ||
| Cardiac arrest | 0 | 2 |
| Cerebrovascular accident (stroke) | 2 | 0 |
| Myocardial infarction (heart attack) | 3 | 1 |
| Thrombophlebitis | 3 | 7 |
| Pulmonary embolism | 2 | 5 |
| Congestive heart failure | 3 | 2 |
| Edema (swelling) | 19 | 17 |
| Dyspnea (shortness of breath) | 11 | 3 |
| Leg cramps | 8 | 11 |
| Upper respiratory discharge | 1 | 1 |
| Hoarseness | 1 | 0 |
| Gastrointestinal | ||
| Nausea | 15 | 8 |
| Diarrhea | 12 | 11 |
| Minor gastrointestinal upset | 11 | 6 |
| Anorexia (appetite loss) | 4 | 3 |
| Flatulence | 2 | 0 |
| Vomiting | 1 | 1 |
| Gastrointestinal bleeding | 1 | 0 |
| Burning throat | 1 | 0 |
| Thirst | 1 | 0 |
| Integumentary | ||
| Rash | 1 | 4 |
| Pruritus (itching) | 2 | 2 |
| Dry skin | 2 | 0 |
| Pigment changes | 0 | 3 |
| Easy bruising | 3 | 0 |
| Flushing | 1 | 0 |
| Night sweats | 0 | 1 |
| Peeling of fingertip skin | 1 | 0 |
| Thinning hair | 1 | 1 |
| Breast changes | ||
| Breast tenderness | 66 | 64 |
| Breast enlargement (gynecomastia or male breast development) | ||
| Mild | 60 | 54 |
| Moderate | 10 | 16 |
| Marked | 0 | 5 |
| Miscellaneous | ||
| Lethargy alone | 4 | 3 |
| Depression | 0 | 2 |
| Emotional lability | 2 | 0 |
| Insomnia | 3 | 0 |
| Headache | 1 | 1 |
| Anxiety | 1 | 0 |
| Chest pain | 1 | 1 |
| Hot flashes | 0 | 1 |
| Eye pain | 0 | 1 |
| Lacrimation (eye tears) | 1 | 1 |
| Tinnitus | 0 | 1 |
| Laboratory abnormalities | ||
| Hematologic (blood) | ||
| Leukopenia (low white blood cells) | 4 | 2 |
| Thrombopenia (low platelets) | 1 | 2 |
| Hepatic (liver) | ||
| Bilirubin alone | 1 | 5 |
| Bilirubin and LDHTooltip lactate dehydrogenase | 0 | 1 |
| Bilirubin and ASTTooltip aspartate transaminase | 2 | 1 |
| Bilirubin, LDH, and SGOT | 2 | 0 |
| LDH and/or SGOT | 31 | 28 |
| Miscellaneous | ||
| Transient hypercalcemia (high calcium) | 0 | 1 |
| Sources: [1] | ||