Template:Plasma levels and binding potential of flutamide and bicalutamide during first week

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Plasma levels and binding potential of flutamide and bicalutamide during first week
Day Total levels (ng/mL) Free levels (ng/mL) Ratios
Bicalutamide Flutamidea Bicalutamide Flutamidea Free Binding potentialb
1 901 940 36.0 66 0.55 2.18
2 1613 1500 64.5 105 0.61 2.46
3 2345 1500 93.8 105 0.89 3.57
4 2969 1500 118.8 105 1.13 4.53
7 4259 1500 170.4 105 1.62 6.49
Notes: During first week of treatment. Dosages not provided. Footnotes: a = As 2-hydroxyflutamide (the active form of flutamide). b = Assumes, on the basis of ligand binding assays, that bicalutamide possesses 4-fold greater affinity for the androgen receptor than 2-hydroxyflutamide. Sources: [1]

References

  1. ^ Blackledge GR (1996). "Clinical progress with a new antiandrogen, Casodex (bicalutamide)". Eur. Urol. 29 Suppl 2: 96–104. doi:10.1159/000473847. PMID 8717470.
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