Template:Major side effects of bicalutamide alone

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Major side effects of bicalutamide alone
Frequency	Class	Side effect
Very common (≥10%)	Reproductive system and breast disorders	• Breast tenderness^a • Gynecomastia^a
Common (≥1% and <10%)	General and psychiatric disorders	• Asthenia • Decreased libido • Erectile dysfunction • Hot flashes
	Skin and subcutaneous tissue disorders	• Decreased body hair
	Hepato-biliary disorders	• Elevated liver enzymes^b
Uncommon (≥0.1% and <1%)	Immune system disorders	• Hypersensitivity reactions, (angioedema and hives)
Rare (<0.1%) and unknown	Respiratory, thoracic, and mediastinal disorders	• Interstitial lung disease^c
	Skin and subcutaneous tissue disorders	• Sensitivity to light
	Hepato-biliary disorders	• Liver toxicity^d
Footnotes and sources ^a = Incidence of breast changes of up to 80 to 90%. Mild-to-moderate in 90% of cases. Incidence greatly decreased in combination with castration. ^b = Elevated liver enzymes rarely severe and usually transient, resolving or improving with continued therapy or with discontinuation. Incidence of 3.4% relative to 1.9% for placebo in a high-dose 4,000-patient trial. ^c = 6 case reports of interstitial lung disease published (as of 2016). Incidence of 0.01% (12 patients) in an 87,000-patient cohort. ^d = 7 case reports of liver toxicity published (as of 2018). No cases in a high-dose 4,000-patient trial (suggesting incidence of <0.03%). Sources: ^[1]^[2]^[3]^[4]^[5]^[6]^[7]

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