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Template:Findings in CD vs. UC

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Diagnostic findings
Crohn's disease Ulcerative colitis
Terminal ileum involvement Commonly Seldom
Colon involvement Usually Always
Rectum involvement Seldom Usually (95%)[1]
Involvement around
the anus		 Common[2] Seldom
Bile duct involvement No increase in rate of primary sclerosing cholangitis Higher rate[3]
Distribution of disease Patchy areas of inflammation (skip lesions) Continuous area of inflammation[1]
Endoscopy Deep geographic and serpiginous (snake-like) ulcers Continuous ulcer
Depth of inflammation May be transmural, deep into tissues[2][4] Shallow, mucosal
Stenosis Common Seldom
Granulomas on biopsy May have non-necrotizing non-peri-intestinal crypt granulomas[2][5][6] Non-peri-intestinal crypt granulomas not seen[7]
  1. ↑ 1.0 1.1 Rubin, DT; Ananthakrishnan, AN; Siegel, CA; Sauer, BG; Long, MD (March 2019). "ACG Clinical Guideline: Ulcerative Colitis in Adults". The American journal of gastroenterology. 114 (3): 384–413. doi:10.14309/ajg.0000000000000152. PMID 30840605.
  2. ↑ 2.0 2.1 2.2 Hanauer SB, Sandborn W (2001-03-01). "Management of Crohn's disease in adults" (PDF). American Journal of Gastroenterology. 96 (3): 635–43. doi:10.1111/j.1572-0241.2001.03671.x. PMID 11280528. Retrieved 2009-11-07.
  3. ↑ Broomé U, Bergquist A (February 2006). "Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer". Seminars in Liver Disease. 26 (1): 31–41. doi:10.1055/s-2006-933561. PMID 16496231.
  4. ↑ Baumgart DC, Sandborn WJ (May 2007). "Inflammatory bowel disease: clinical aspects and established and evolving therapies". The Lancet. 369 (9573): 1641–57. doi:10.1016/S0140-6736(07)60751-X. PMID 17499606. Retrieved 2009-11-04.
  5. ↑ Shepherd NA (August 2002). "Granulomas in the diagnosis of intestinal Crohn's disease: a myth exploded?". Histopathology. 41 (2): 166–8. doi:10.1046/j.1365-2559.2002.01441.x. PMID 12147095.
  6. ↑ Mahadeva U, Martin JP, Patel NK, Price AB (July 2002). "Granulomatous ulcerative colitis: a re-appraisal of the mucosal granuloma in the distinction of Crohn's disease from ulcerative colitis". Histopathology. 41 (1): 50–5. doi:10.1046/j.1365-2559.2002.01416.x. PMID 12121237.
  7. ↑ DeRoche, TC; Xiao, SY; Liu, X (August 2014). "Histological evaluation in ulcerative colitis". Gastroenterology report. 2 (3): 178–92. doi:10.1093/gastro/gou031. PMID 24942757.
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