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Apoptosis signaling pathway
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t
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Apoptosis
signaling pathway
Fas path
Ligand
Fas ligand
Receptor
Fas receptor
Intracellular
Death-inducing signaling complex
DAXX
ASK1
FADD
Caspase 8
BID
Cytochrome c
Caspase 9
Caspase 3
Bcl-2 family
Pro-apoptotic:
BAX
BAK1/
Bcl-2 homologous antagonist killer
Bcl-2-associated death promoter
Anti-apoptotic:
Bcl-2
Bcl-xL
TNF path
Ligand
Tumor necrosis factor alpha
Receptor
Tumor necrosis factor receptor 1
Tumor necrosis factor receptor 2
Intracellular
TRADD
FADD
Caspase 8
Caspase 3
BID
TRAF2
ASK-1
MEKK1
IKK
IκBα
MKK7
JNK
NF-κB
Other
Intracellular
IAPs
XIAP
NAIP
Survivin
c-IAP-1
c-IAP-2
Apoptosis-inducing factor
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Signaling pathway templates
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