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- Target lesions are the typical lesions of erythema multiforme, in which a vesicle is surrounded by an often hemorrhagic maculopapule. Erythema multiforme is often self-limited, of acute onset, resolves in three to six weeks, and has a cyclical pattern. Its lesions are multiform (polymorphous) and include macules, papules, vesicles, and bullae.
- Target lesions are also typical of Lyme disease. In the context of Lyme disease, the target lesion is synonymous with erythema migrans (erythema chronicum migrans), although not everyone who gets Lyme disease will have a target-shaped rash, and some will have no rash at all.
Target lesion consists of three zones :
- Dark centre of small papule, vesicle, or bulla (iris)
- Pale intermediate zone
- Peripheral rim of erythema