Talk:Pernicious anemia

Source [7] & issues with data

Source 7 no longer exists, please link to the archive. Also, As far as I'm aware, it is impossible to gain B12 through a pill when the cause is through lack of intrinsic factor. Lacking intrinsic factor is what causes Pernicious Anemia to be an issue, and is why B12 is not absorbed through the body. A pill would not solve this, as, well, pills are absorbed through the stomach just as regular food is, and as such will be ignored due to the lack of intrinsic factor. As far as I am aware, this is only solvable with injections. — Preceding unsigned comment added by 31.121.173.154 (talk) 00:31, 1 February 2024 (UTC)

Exactly. Anyone with this illness should not be persuaded to buy B12 supplements as they won't work. 70.49.18.153 (talk) 20:03, 14 March 2024 (UTC)

April edits

I added some info about PA in a nice edit. Left to add is the relationship between PA and atrophic gastritis...

Understandable?

Do you current editors think this article is understandable? I stated in a previous entry that readers can look up the words they do not know, but is that fair enough? I'm just trying to keep this as legit, helpful, and understandable as possible for everyone. Thanks! OnFire4Jesus (talk) 03:17, 23 March 2008 (EST)

NEUROLOGICAL manifestations:

Neurological manifestations of B12 deficiency include:

Dementia,

Posterlateral sclerosis of the spinal cord,

peripheral neuropathy,

anosmia, and

optic nerve disease.

Pernicious anemia most usually presents via neurological symptoms in societies where food is fortified with folic acid (because folate-fortified foods obscure the better known megaloblastic anemia seen in red blood cells when inadequate B12 is accompanied by inadequate folate.

Epidemiology - self-contradiction

In leading section "Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition.". In Epidemiology section "PA is estimated to affect 0.1% of the general population and 1.9% of those over 60". Both statements have different citations, which support the figures given. BUT in US according to a quick Google search, ~16.8% of population is over 65 (so more than that must be over 60). 1.9% of 16.8% is 0.019 x 0.168 = 0.0032. So even if no-one under 65 has the condition, there should be over 3 per 1000 people with PA. I have no idea whether the correct figure is ~1 per 1000, or >3 per 1000, but they can't both be right.Newburyjohn (talk) 07:42, 31 May 2023 (UTC)

Are all citations fom the same date? from the same location? details do differ, as do raw data. — Preceding unsigned comment added by 70.49.18.153 (talk) 20:05, 14 March 2024 (UTC)

Psychiatric Conditions

https://pubmed.ncbi.nlm.nih.gov/20815176/ https://pubmed.ncbi.nlm.nih.gov/26345354/ hhttps://pubmed.ncbi.nlm.nih.gov/8321344/ https://pubmed.ncbi.nlm.nih.gov/15671130/ and last, but not least, a major recent paper which outlines the devastation PA can cause - including in one's mind. Tme for the medical profession to create a particular niche for this protean disorder:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030741/pdf/nutrients-14-01672.pdf 70.49.18.153 (talk) 20:11, 14 March 2024 (UTC)

I've done you a favour - clearer intro - but I can't add links.

Pernicious anemia (PA) is a multi-factorial disease that may affect the central nervous system, the stomach, and the bone marrow, among others, due to the importance of cobalamin vitamin B₁₂. in bodily functions. It may first be misdiagnosed as a psychiatric disorder but frequently is discovered on a blood test. In PA not enough, or macrocytic, red blood cells are produced due to the deficiency. The illness most often has a gradual onset. Common initial symptoms are feeling tired and weakness due to anemia. Other symptoms may include shortness of breath, feeling faint, a smooth red tongue, pale skin, chest pain, nausea and vomiting, loss of appetite, heartburn, numbness in the hands and feet, difficulty walking, memory loss, muscle weakness, poor reflexes, blurred vision, clumsiness, depression, and confusion. Treatment is always necessary as the disease may otherwise lead to permanent consequences and death - which was always the case before cobalamin was synthesized. 70.49.18.153 (talk) 20:52, 14 March 2024 (UTC)

References

The gold standard of current knowledge

[1]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030741/

THIS is the article from which you should be taking updated information on Pernicious Anemia, which does not always show on a blood smear, doesn't necessarily cause stomach cancer, and the patients with which are not particularly well-served with the simple expedient of x hydrocobalamin every y weeks.

When hydrocobalamin was found to be effective in treating PA, it was assumed that everything frum then on would be rosy. And it was assumed that because it was a "rare disease" further research would be a very low priority.

Medicine now has to deal with far more PA patients, with far wider scope of signs and symptoms, than ever assumed. It may even turn out that PA is not a rare or orphan disease. To quote the paper: ". . . PA associated with common variable immunodeficiency, low serum immunoglobulin concentrations, selective IgA deficiency, or the childhood PA, should be distinguished from classic PA". PA is not a straightforward disease. It can be caused in several different ways, all involving the immune system, and can present in a multiplicity of ways. It cam be erroneously diagnosed as Multiple Sclerosis - based on a patient's having sustained nerve damage in a similar fashion, i.e. the fatty insulation around nerves suffers failure. Etc. 70.49.18.153 (talk) 19:38, 2 April 2024 (UTC)