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The article states that tachyphylaxis and tolerance are synonymous; this is not quite true. Tolerance refers to anything that decreases the biological response to a drug and refers to both short and long-term mechanisms. Tachyphlaxis is a subtype of tolerance that refers to rapid, short-term blunting of the response (a good example is drugs that release monoamines; once all the monoamines have been released and depleted, any further administration of the drug does not produce an added response. This is also in contrast to receptor down-regulation which occurs usually over weeks to months and is distinct from tachyphylaxis. Sources: Katzung and Lange Basic and Clinical Pharmacology 10 ed., pg 30-31. Rapid Review Pharmacology, 3rd ed. pg 20. 2nd yr medical student.Biochick90 (talk) 03:22, 8 August 2011 (UTC)[reply]
