Talk:Suicide inhibition

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 24 March 2020 and 29 April 2020. Further details are available on the course page. Student editor(s): Grundsh.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 10:24, 17 January 2022 (UTC)[reply]

Untitled

What is a beta-gamma unsaturated carbon? How can a carbon atom be beta-gamma unsaturated? I also believe that there are other reactive intermediates formed, besides the three listed. For instance, Diisopropylfluorophosphate does not form any of the intermediates listed.

"normal"

"is a form of irreversible enzyme inhibition that occurs when an enzyme binds a substrate analogue and forms a complex with it during the "normal" catalysis reaction." This is very unclear? I am in my second year of chemistry and the explanation offered on the mechanism behind suiced inhibition is at best unclear. I understand what is meant but i think it needs a major rewrite: Suicide inhibition is the irrevesible inhibition of an enzyme by a substrate. It does this by undergoing some basic steps of the intented enzymatic reaction but instead of being releassed from the active site, the inhibitor has become a highly reactive complex which binds very strongly (and therefore irrevesibly) to the active site, thus achiving the permanent inhibition. Its called suicide inhibition because the inhibitor (and the enzyme) is destroyed. Is this any better? I am new to wikipedia and dont know how to go about editing... —Preceding unsigned comment added by Leonidaslundell (talk • contribs)

I'm not sure it has to bind to the active site. I'll check on that. David D. (Talk) 15:03, 15 September 2006 (UTC)[reply]

This page needs to list some references and further reading

Asd28 06:08, 3 July 2007 (UTC)[reply]

Completely made up term, "suicide inhibition"

studying and practicing medicine for 15 years, and i've never hear of this term. Sounds made up. Checked to see if there were references, and there were none. Page should be removed unless there are references. — Preceding unsigned comment added by 110.174.64.8 (talk) 11:18, 12 August 2011 (UTC)[reply]

The term is not a neologism. It is from medicinal chemistry and drug-design research, more than from the practice of medicine, so experience as a practicing physician would not guarantee exposure to it. A PubMed search on "suicide inhibition" (be sure to include the quotation marks in the search term, so as to minimize the crosstalk from articles about actual human suicide) quickly turns up articles that use the term in their titles and abstracts. Example titles: "Computational insights into the suicide inhibition of Plasmodium falciparum Fk506-binding protein 35" and "Suicide Inhibition of Cytochrome P450 Enzymes by Cyclopropylamines via a Ring-Opening Mechanism: Proton-Coupled Electron Transfer Makes a Difference". Searching on "suicide substrate" (the more common form) or "suicide inhibitor" turns up more examples (again, include the quotes); example title: "Rasagiline, a suicide inhibitor of monoamine oxidases, binds reversibly to α-synuclein".

—Syrenka V (talk) 06:43, 2 February 2018 (UTC)[reply]

I agree that this term is should not be used as an article title but can redirect to a page titled "Covalent inhibitors." Some of these "suicide inhibs" have some reversability so there is no "suicide." The term may come from a textbook and be used in articles but it is not frequent at all. A recent paper titled "The taxonomy of Covalent Inhibitors" does not mention suicide and is the current best review of this subject. I will be updating this page and combining it with [agonist] [antagonist] and Targeted covalent inhibitors soon. These are all based on covalent inhibition yet there is no page for this. Jlf3756 (talk) 15:36, 25 July 2018 (UTC)[reply]

I wanted to add that there are other types of irreversible (suicide) inhibitors other than mechanism based, particularly classical and quiescent affinity labels Discovery of Halopyridines as Quiescent Affinity Labels. These are why I think this should be moved to a larger page on covalent inhibitors. Jlf3756 (talk) 18:38, 25 July 2018 (UTC)[reply]

The term "suicide substrates/inactivators" was made up in 1970s (Enzyme inhibitors, Basel 1980, ISBN 3-527-25893-0 or ISBN 0-89573-037-5) and it is quite utilised by professionals who are not from medicine.

I merged them now. Somebody with an account may rename the article.217.214.145.96 (talk) 13:20, 12 October 2018 (UTC)[reply]

Suicide inhibition has significant modern use in the field of pharmacology research, used even in the title of peer-reviewed articles. See, for example:

Pham, KN; Yeh, SR (7 November 2018). "Mapping the Binding Trajectory of a Suicide Inhibitor in Human Indoleamine 2,3-Dioxygenase 1". Journal of the American Chemical Society. 140 (44): 14538–14541. doi:10.1021/jacs.8b07994. PMID 30347977.
Ichimaru, Y; Fujii, T; Saito, H; Sano, M; Uchiyama, T; Miyairi, S (1 September 2017). "5-Bromoindirubin 3'-(O-oxiran-2-ylmethyl)oxime: A long-acting anticancer agent and a suicide inhibitor for epoxide hydrolase". Bioorganic & medicinal chemistry. 25 (17): 4665–4676. doi:10.1016/j.bmc.2017.07.009. PMID 28743492.
Kakish, J; Tavassoly, O; Lee, JS (18 February 2015). "Rasagiline, a suicide inhibitor of monoamine oxidases, binds reversibly to α-synuclein". ACS chemical neuroscience. 6 (2): 347–55. doi:10.1021/cn5002914. PMID 25514361.

So, the term both has a long history and is in current use. Irreversible antagonist is usually used to describe an effect on a receptor, whereas suicide inhibition is more commonly used for enzymes. So, I recommend merging the suicide inhibition page to better-quality section at Enzyme inhibitor#Irreversible inhibitors, but not merging with the antagonist page (and certainly not the agonist page) as their functions related to receptors.

This page explains the cause, but not the effect of this process.