Talk:Psoriasis

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PASI score

PASI stands for Psoriasis Area and Severity Index. PASI includes the amount of body surface area that is affected by psoriasis in addition to three major symptoms: redness, inflammation, and the thickness of the scale on the skin. A patient is given a PASI score from 0-72 where 0 means no psoriasis and 72 means the most severe psoriasis. A PASI score is given to a patient before treatment and then after treatment to determine the effectiveness of the therapy. The goal of successful psoriasis treatment is to reduce the PASI score as close to 0 (no psoriasis) as possible.

Ultraviolet info seems self-contradictory

Ultraviolet wavelengths are subdivided into UVA (380–315 nm), UVB (315–280 nm), and UVC (< 280 nm). Ultraviolet B (UVB) (315–280 nm) is absorbed by the epidermis and has a beneficial effect on psoriasis. Narrowband UVB (311 to 312 nm), is that part of the UVB spectrum that is most helpful for psoriasis.

Query: If UVA is from 380-315 nm, it includes 311-312 nm. So how come Narrowband UV (311 to 312 nm) is supposed to be UVB instead of UVA?

Answer: 380-315nm does not included 311-312nm. 311-312 is less than 315.

Mention the generic (calcitriol) along with the patented (calcipotriol)?

Moisturizers and emollients such as mineral oil, petroleum jelly, calcipotriol or calcitriol, and decubal (an oil-in-water emollient) were found to increase the clearance of psoriatic plaques. Emollients have been shown to be even more effective at clearing psoriatic plaques when combined with phototherapy.[1] However, certain emollients have no impact on psoriasis plaque clearance or may even decrease the clearance achieved with phototherapy. The emollient salicylic acid is structurally similar to para-aminobenzoic acid (PABA), commonly found in sunscreen, and is known to interfere with phototherapy in psoriasis. Coconut oil, when used as an emollient in psoriasis, has been found to decrease plaque clearance with phototherapy.[1] Medicated creams and ointments applied directly to psoriatic plaques can help reduce inflammation, remove built-up scale, reduce skin turnover, and clear affected skin of plaques. Ointment and creams containing coal tar, dithranol, corticosteroids (i.e. desoximetasone), fluocinonide, vitamin D3 analogs (for example, calcipotriol or calcitriol), and retinoids are routinely used. The use of the finger tip unit may be helpful in guiding how much topical treatment to use.[2][3]


References

  1. ^ a b Asztalos ML, Heller MM, Lee ES, Koo J (May 2013). "The impact of emollients on phototherapy: a review". J Am Acad Dermatol. 68 (5): 817–24. doi:10.1016/j.jaad.2012.05.034. PMID 23399460.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Cite error: The named reference Clarke2011 was invoked but never defined (see the help page).
  3. ^ Menter A, Korman NJ, Elmets CA, Feldman SR, Gelfand JM, Gordon KB, Gottlieb A, Koo JY, Lebwohl M, Lim HW, Van Voorhees AS, Beutner KR, Bhushan R; American Academy of Dermatology (2009). "Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 3. Guidelines of care for the management and treatment of psoriasis with topical therapies". J Am Acad Dermatol. 60 (4): 643–59. doi:10.1016/j.jaad.2008.12.032. PMID 19217694.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Improvement suggestion from a person editing with IP address

Hi, I was just reviewing a recent edit made by someone from an IP address that suggested we include the following evidence in the article:

  • "Recent study demonstrates that bacterial and fungal proteases are able to activate the inflammatory cytokine interleukin-36γ, suggesting a possible microbial trigger or etiology for psoriasis.[1]"

This looks like an interesting research paper. Adding evidence to Wikipedia is a little different from an academic review article in that in most cases, Wikipedia articles only include evidence that has undergone a secondary review. I can see that this is a primary research paper that was just published a few days ago. My idea was to include this on the talk page so that we can look for a recent review that may summarize preliminary work or similar studies, or we wait for this paper to be included in a systematic review or clinical guideline (or any source appropriate for Wikipedia as per WP:MEDRS. If the person editing from an IP address has any ideas the include, this is a great place to post them! JenOttawa (talk) 13:52, 18 December 2020 (UTC)[reply]

@MrOllie: thanks for your efforts to reach out to this editor. It is great to see content experts and researchers here to improve articles and Wikipedia. I left a message on their talk page, but I am not sure how notifications work for IP addresses. I can see that it has now been added back in. JenOttawa (talk) 14:41, 18 December 2020 (UTC)[reply]

References

  1. ^ Macleod, Thomas; Ainscough, Joseph S.; Hesse, Christina; Konzok, Sebastian; Braun, Armin; Buhl, Anna-Lena; Wenzel, Joerg; Bowyer, Paul; Terao, Yutaka; Herrick, Sarah; Wittmann, Miriam; Stacey, Martin (December 2020). "The Proinflammatory Cytokine IL-36γ Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues". Cell Reports. 33 (11): 108515. doi:10.1016/j.celrep.2020.108515.

Lancet seminar

doi:10.1016/S0140-6736(20)32549-6 JFW | T@lk 17:33, 2 April 2021 (UTC)[reply]

How did they get 2A02:C7C:C460:4000:7974:9FE9:2B77:5CD4 (talk) 20:51, 5 November 2023 (UTC)[reply]

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