Talk:Oxazepam

Opamox

That's another brand name for this drug, but I'm not sure it's big enough to be listed in the article or if it's just used in my little country of Finland. --84.249.212.126 10:05, 4 September 2007 (UTC)

I say, edit. That's how they usually do it, and I just added the swedish brand named. Although we aren't a "little country". —Preceding unsigned comment added by 83.254.23.154 (talk) 10:52, 3 February 2011 (UTC)

Tolerance

In the tolerance experiment, brain concentrations increase compared to the single dose, proportional with tolerance. This is not a CONSEQUENCE of tolerance but a consequence of the repeated dosing with higher doses, brain levels reaching steady state equilibrium. As such, it says nothing about the consequences of tolerance, but about the consequences of repeated dosing to steady state. Deleted for lack of pharmacological significance. Of course are steady state values higher in a multi compartment model, than are single dose responses. Only my lay opinion. 70.137.181.232 (talk) 14:07, 16 July 2008 (UTC)

Fair enough, lets leave it deleted. Oxazepam is short acting though but still some accumulation can occur with short acting compounds.--Literaturegeek | T@1k? 14:29, 16 July 2008 (UTC)

Relatively weak?

Relatively weak anxiolytic? Relative to same dose in milligrams of diazepam, right? Because properly dosed oxazepam (3 - 3.5 times dose of diazepam) is fairly potent anxiolytic, useful even in prevention of delirium tremens in alcoholics on detox.--84.163.111.190 (talk) 01:15, 30 July 2008 (UTC)

I have never heard of oxazepam being used in detox to prevent delirium tremens. If it is used it is not used very often. It probably would help prevent delerium tremens as would most if not all benzodiazepines but it wouldn't be the most effective one. It is diazepam (valium) and chlordiazepoxide (librium) which are most often used to control delirium tremens and sometimes booster shots of lorazepam (ativan) if delirum tremens breaks through the diazepam and chlordiazepoxide. Oxazepam would not be good for detoxing alcoholics due to it's short half life anyway and it not being as potent as other benzodiazepines. I have never seen it recommended anywhere before for detoxing alcoholics in the literature or in addiction centers. Oxazepam is moderately potent compared to other benzodiazepines due to it's relatively slow penentration of the blood brain barrier and does not as potently as other benzodiazepines stimulate the benzodiazepine receptor.--Literaturegeek | T@1k? 02:34, 30 July 2008 (UTC)

The word weak was misleading, I changed it to moderate.--Literaturegeek | T@1k? 02:37, 30 July 2008 (UTC)

In Germany, Austria and some other mid-European lands, for instance, it is sometimes used in prevention of delirium tremens (though diazepam and the non-BZD clomethiazole are usualy the 1st line drugs). Short half-live, absence of active metabolites or slow penetration of biomembranes/resorption, high polarity of the substance don't play a role really, if properly dosed (30 - 50 mg t.i.d. - q.i.d.). And its potency isn't that low, as I wrote, it's somewhere around 25 - 35% of that of diazepam. It's all about dose; its short half-life, rel. slow resorption, lack of oxidative metabolism and active metabolites are of value in some patients (elderly, children, polymedicated etc.)--84.163.111.190 (talk) 03:48, 30 July 2008 (UTC)

Drugbox

The image(s) are hiding much of the data. I am not sure how to fix this. D A Patriarche (talk) 19:53, 24 February 2014 (UTC)