Talk:Methamphetamine

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Good articleMethamphetamine has been listed as one of the Natural sciences good articles under the good article criteria. If you can improve it further, please do so. If it no longer meets these criteria, you can reassess it.
Did You Know Article milestones
DateProcessResult
December 9, 2006Featured article candidateNot promoted
December 10, 2006Peer reviewReviewed
December 26, 2008Good article nomineeNot listed
January 27, 2014Good article nomineeListed
Did You Know A fact from this article appeared on Wikipedia's Main Page in the "Did you know?" column on November 3, 2005.
The text of the entry was: Did you know ...that Ice is a highly addictive methamphetamine and that when it is smoked it causes a massive release of dopamine in the brain?
Current status: Good article

Semi-protected edit request on 15 January 2023

Dextroamphetamine is a stronger CNS stimulant than levomethamphetamine.

Dextroamphetamine needs to be changed to dextromethamphetamine as this sentence was originally stating the stronger CNS stimulation of the dextro enantiomer of methamphetamine, not amphetamine. 76.8.183.219 (talk) 16:55, 15 January 2023 (UTC)[reply]

 Not done: please provide reliable sources that support the change you want to be made. ~ Eejit43 (talk) 01:30, 18 January 2023 (UTC)[reply]
There is no source here supporting this comparison of D-amph to L-meth.
Source [124] sort-of-supports changing this, although I personally think "stronger" is a vague term to use here. 82.170.165.135 (talk) 11:21, 23 January 2023 (UTC)[reply]

Where's the dextromethamphetamine page?

We have a levometh page but not for dextrometh? And why is the dextrometh link, which is supposed to be non-existent because the page hasn't been created, link back to the racemic methamphetamine page? Someone kinda needs to fix that and add an actual dextromethamphetamine page. Doxylamine (talk) 21:58, 22 May 2023 (UTC)[reply]

Semi-protected edit request on 7 July 2023

Change A: Methamphetamine < Uses < Medical

"In the United States, methamphetamine hydrochloride, under the trade name Desoxyn, has been approved by the FDA for treating ADHD and obesity in both adults and children;[24][25] however, the FDA also indicates that the limited therapeutic usefulness of methamphetamine should be weighed against the inherent risks associated with its use.[24] To avoid toxicity, FDA guidelines recommend methamphetamine at doses 25mg/day for ADHD in adults and children over six years of age.[5] Methamphetamine is sometimes prescribed off label for narcolepsy and idiopathic hypersomnia.[26][27] In the United States, methamphetamine's levorotary form is available in some over-the-counter (OTC) nasal decongestant products.[note 3]"

To Change B: Methamphetamine < Uses < Medical

"In the United States, methamphetamine hydrochloride, under the trade name Desoxyn, has been approved by the FDA for treating ADHD and obesity in both adults and children;[24][25] however, the FDA also indicates that the limited therapeutic usefulness of methamphetamine should be weighed against the inherent risks associated with its use.[24] To avoid toxicity and a risk of side effects, FDA guidelines recommend the initial dose of methamphetamine at doses 5-10mg/day for the treatment of ADHD in adults, and for the treatment of ADHD and obesity in children over six years of age. If a patient's therapeutic dose has not been reached, the dose may be increased by 5mg in weekly intervals until the optimum clinical response is found. The usual effective dose is around 20-25mg, however some people may find lower doses to be more therapeutic. "Methamphetamine should be administered at the lowest effective dosage, and dosage should be individually adjusted."[1][5] If required, a daily dose may be divided into 2 effective doses. Methamphetamine is sometimes prescribed off label for narcolepsy and idiopathic hypersomnia in doses up to 60mg.[5][26][27] In the United States, methamphetamine's levorotary form is available in some over-the-counter (OTC) nasal decongestant products.[note 3]

References

The explanation for my edit request:


Contained within the "Uses" and "Medical" section for methamphetamine, there is a distressing error that claims, "To avoid toxicity, FDA guidelines recommend methamphetamine at doses 25mg/day for ADHD in adults and children over six years of age."

This is misleading, considering that a beginning dose, 25mg of methamphetamine, is NOT recommended by the FDA for the treatment of ADHD in adults, as well as the treatment of ADHD and obesity in children over six years of age without an observed clinical trial. A dose of 25mg is only "recommended" in the treatment of ADHD (Or a child's obesity) after testing a patient's dose-responsive relationship.

Reference [5] states that, "Methamphetamine is used as a secondary treatment for attention deficit hyperactivity disorder (ADHD) in children over the age of six and for the short-term management of exogenous obesity. Used in this context, the FDA has approved the administration of methamphetamine at doses of up to 25 mg/day."

Stated within the Desoxyn Prescribing Information PDF, reference 24, and according to "[Dailymed]",

"For treatment of children 6 years or older with a behavioral syndrome characterized by moderate to severe distractibility, short attention span, hyperactivity, emotional lability and impulsivity: an initial dose of 5 mg DESOXYN once or twice a day is recommended. Daily dosage may be raised in increments of 5 mg at weekly intervals until an optimum clinical response is achieved. The usual effective dose is 20 to 25 mg daily. The total daily dose may be given in two divided doses daily."

I suggest that we revise the Medical section of methamphetamine to become more informative and to ensure maximum risk prevention. Seventeenyearoldchemist (talk) 22:44, 7 July 2023 (UTC)[reply]

 Done --WikiLinuz {talk} 01:06, 8 July 2023 (UTC)[reply]
I appreciate the quick fix. Thanks for updating my talk page as well!
I also like how you improved the readability of the edit through the use of semicolons.
I was debating whether I should've included that Desoxyn can be prescribed for Narcolepsy at up to 60mg, but I later realized that it was unnecessary to include the maximum dosages because the clinical period is probably the same for somebody being prescribed methamphetamine for narcolepsy. Thanks for catching that and shortening up the edit! Seventeenyearoldchemist (talk) 07:25, 8 July 2023 (UTC)[reply]

Semi-protected edit request on 18 July 2023

Reason for edit: Small grammatical error.

Change A: In the United States, methamphetamine hydrochloride, under the trade name Desoxyn, has been approved by the FDA for treating ADHD and obesity in both adults and children;[24][25] however, the FDA also indicates that the limited therapeutic usefulness of methamphetamine should be weighed against the inherent risks associated with its use.[24] To avoid toxicity and risk of side effects, FDA guidelines recommend initial dose of methamphetamine at doses 5-10mg/day for ADHD in adults and children over six years of age, and may be increased at weekly intervals of 5mg, up to 25mg/day, until optimum clinical response is found; the usual effective dose is around 20-25mg/day.[5][24] Methamphetamine is sometimes prescribed off label for narcolepsy and idiopathic hypersomnia.[26][27] In the United States, methamphetamine's levorotary form is available in some over-the-counter (OTC) nasal decongestant products.[note 3]

Change B: In the United States, methamphetamine hydrochloride, under the trade name Desoxyn, has been approved by the FDA for treating ADHD and obesity in both adults and children;[24][25] however, the FDA also indicates that the limited therapeutic usefulness of methamphetamine should be weighed against the inherent risks associated with its use.[24] To avoid toxicity and risk of side effects, FDA guidelines recommend an initial dose of methamphetamine at doses 5-10mg/day for ADHD in adults and children over six years of age, and may be increased at weekly intervals of 5mg, up to 25mg/day, until optimum clinical response is found; the usual effective dose is around 20-25mg/day.[5][24] Methamphetamine is sometimes prescribed off label for narcolepsy and idiopathic hypersomnia.[26][27] In the United States, methamphetamine's levorotary form is available in some over-the-counter (OTC) nasal decongestant products.[note 3] Seventeenyearoldchemist (talk) 02:55, 18 July 2023 (UTC)[reply]

 Done - FlightTime (open channel) 03:00, 18 July 2023 (UTC)[reply]

Dextroamphetamine stronger stimulant than levomethamphetamine

Accidentally said levoamphetamine instead of levomethamphetamine in my edit summary but I still don’t see how it’s relevant, particularly right there. Seems pretty random and I don’t see the point of comparing an isomer of methamphetamine to one of amphetamine when it’s not even comparing the same type of isomer. Comparing potency of dextroamphetamine to dexromethamphetamine would make exponentially more sense (in the intro). Dexedream (talk) 01:04, 22 July 2023 (UTC)[reply]

Hmm. I tend to agree; that seems like a weird comparison without additional context, especially given that it's in the lead. Ranked by psychostimulant potency, it's: dextromethamphetamine > dextroamphetamine > levoamphetamine > levomethamphetmaine. I know I've read this in a handful of sources before, so it shouldn't be difficult to cite. If a comparison between amphetamine and methamphetamine enantiomers is included at all, then all 4 should probably be mentioned. Otherwise, I think cutting it seems justified. Also, while levomethamphetamine technically is a CNS stimulant, it's a fairly weak one in comparison to the other enantiomers, particularly considering that it's sold OTC in the United States as a nasal decongestant. Seppi333 (Insert ) 01:43, 22 July 2023 (UTC)[reply]
I think that information would be very useful for readers, so I think it should be included.
Another editor recently moved the page levomethamphetamine to levmetamfetamine. It would benefit a review from you. --WikiLinuz {talk} 15:14, 22 July 2023 (UTC)[reply]
@JoeBo82: I appreciate you being proactive about moving pages on drug articles to their INN pagename. There are, however, a handful of exceptions to the MOS:PHARM#Articles to use INN naming convention on drugs (see the first note), and you incidentally happened to come across one of those exceptions with levomethamphetamine. Just wanted to give you advance notice that I'll swap back the pagenames sometime in the near future. Since the page has fairly low traffic, this isn't a matter of any particular urgency. Seppi333 (Insert ) 21:00, 23 July 2023 (UTC)[reply]
Where is the arbitration or discussion that determined this should be the case? I checked the Manuals of Style, but couldn’t find such a supposed exception. If you could let me know, that would be appreciated. JoeBo82 (talk) 01:17, 24 July 2023 (UTC)[reply]
@JoeBo82: I mean ... you could check the MOS:PHARM talk page archives and search for discussions about "INN" if you want to read the discussion about the use of the INN as the pagename and exceptions to this rule, but that's a bit unnecessary given what's actually written on MOS:PHARM. The exceptions to using the INN and when to use a different common name as the pagename is explicitly stated on the MOS page, and the particular exceptions for methamphetamine and several amphetamine derivatives are stated as examples on the MOS page as well. To quote MOS:PHARM#Articles to use INN directly: "A drug article should be titled according to its International Nonproprietary Name (INN), also known as recommended International Nonproprietary Name (rINN), if one exists, except in unusual circumstances where another common name is more appropriate.[nb 1]"
  1. ^ Notable exceptions include lysergide, amfetamine, metamfetamine, diamorphine, and tenamfetamine, which redirect to an article title that differs from the INN listed here.
    Category:Infobox drug articles with non-default infobox title contains an updated list of of articles that don't follow this article title guideline and include the INN in the drugbox INN parameter; these articles are listed under the underscore section.
As a convention, most substituted amphetamines that are also prescription drugs don't use the INN, as is evident from the tracking category entries below. Their INNs are much less recognizable than the names derived from the amphetamine contraction (i.e., the common names that are used instead) in English-speaking countries. As a rather extreme example, I doubt even 1% of the general population would even recognize MDMA by its INN.
Drugbox tracking category entries for pages that don't use their INN as the pagename
Seppi333 (Insert ) 02:09, 24 July 2023 (UTC)[reply]
That’s methamphetamine, racemic, not enantiopure levmetamfetamine which is being referred to. JoeBo82 (talk) 02:21, 24 July 2023 (UTC)[reply]
Uhm... I'm pretty sure if the racemate is common name, then the dextro and levo enantiomers have the same common name. If you want to make a big fucking deal about this and draw other editors in simply because you don't like being reverted, then we can go back through the motions all over again. But, there's virtually no way you're going to convince everyone to keep the INN of that page the way it is given previous discussions about these article names. Also, using an INN for an enantiomer and a different common name for the racemate in their respective articles is just weird. Seppi333 (Insert ) 02:39, 24 July 2023 (UTC)[reply]
Where’s this supposed “big fucking deal” you’re whining about? I was nothing but polite to you. JoeBo82 (talk) 03:02, 24 July 2023 (UTC)[reply]
True, but I wouldn't expect to be immediately reverted by someone non-combative.
Not trying to be a dick, but you need to understand there has been a lot of discussion about these article names in the past. It's not like MOS:PHARM is just ignored on amphetamine, dextroamphetamine, methamphetamine, and levomethamphetamine. I mean, one of those is an FA and this page is a GA. Obviously, the pagenames have been discussed ad nauseum. I just don't remember if they primarily took place on this page, talk:amphetamine, WT:MED, WT:PHARM, or MOS:PHARM, and I don't particularly feel like searching through all 5 talk page archives right now. If you really want to read the relevant discussions, I'll link them for you later tonight or tomorrow. But again, I don't really see why you find it necessary given the fact that for basically any guidance to be written into a project MOS, it has to be discussed ad nauseum on the talk page first. So, you already know you'll find a consensus there. Seppi333 (Insert ) 03:16, 24 July 2023 (UTC)[reply]

Methamphetamine Hcl =\= Crystal meth? Also physical dependence

Also while I’m here, is there actually a source that says methamphetamine hydrochloride (HCl) is the crystallized form of methamphetamine because that sounds sort of contradictory to me but maybe I just don’t know enough about chemistry. I thought hydrochloric salts were literally removed from certain drugs (such as cocaine) to make them “smokable” (unless it’s a case by case thing), and from what I understand crystallized methamphetamine was first introduced specifically to be smoked.

Admittedly I’m not sure on that one about the hydrochloride form but I do know for a fact that physical dependence saying “none” is undoubtedly incorrect. This notion that only downers cause genuine physical dependencies is getting pretty old. Not just on Wikipedia but in the drug/“scientific”/autodidact community in general. It really makes no sense and it treats neurological dependence like something which somehow isn’t “physical” merely because the symptoms are not somatic. The symptoms may not be “physical” but the dependency itself certainly is. Even coffee causes physical/neurological dependence. It seems to just be harping on the grossly outdated idea that stimulant dependencies are ‘fictive’ or just “in your head” with no palpable mechanisms which is clearly not the case. Meanwhile we have the other extreme going on with the cocaine article where people keep insisting on putting “high physical dependence” propensity which seems just as senseless. I can’t see any justifications for the meth/cocaine articles saying anything other than “moderate” in regards to the physical dependence sections. Maybe moderate - high at most. But just shamelessly saying straight up “high” or “none” is pretty ridiculous and essentially impossible to justify.Dexedream (talk) 01:20, 22 July 2023 (UTC)[reply]

This is the image we use to illustrate methamphetamine hydrochloride (crystal meth). Compare this to this google image search. Pure, unadulterated methamphetamine hydrochloride looks like a translucent white crystal, hence the name.
The distinction between physical dependence and psychological dependence is literally just based on whether withdrawal symptoms are physical/somatic or cognitive. Drug dependence - the more general concept - can entail either or both, depending on the drug. Physical/somatic withdrawal symptoms are easily observable/measurable. E.g., ethanol can induce delirium tremens and opioid withdrawal involves "restless legs, nausea, vomiting, diarrhea, sweating, and an increased heart rate", per the lead of that article. All of those symptoms reflect a withdrawal syndrome associated with physical dependence. The symptoms I didn't quote from the lead - given that they're cognitive in nature - reflect psychological dependence. That being said, I don't see where in this article or cocaine the occurrence of physical dependence is mentioned. They shouldn't state this because neither one - nor virtually any other psychostimulant drug - induces physical/somatic withdrawal symptoms after repeated use. Seppi333 (Insert ) 02:03, 22 July 2023 (UTC)[reply]
Addendum: here's a source for the name reflecting the HCL salt. Seppi333 (Insert ) 02:09, 22 July 2023 (UTC)[reply]
Well I don’t see what that link has to do with dependence since that word isn’t even mentioned, nor do I see how it’s even a remotely reputable source. I bet I could scour that site and find dozens of bits of misinformation. I’ve found worse from “better sites” after all. At the end of the day many “professionals” don’t even care about the details or the technical nuances, they’re just doing a job and want to finish and get home like everybody else. Dexedream (talk) 16:49, 29 July 2023 (UTC)[reply]
yeah that makes no sense because obviously the mechanisms which cause psychological symptoms are still very physical regardless, therefore the dependence itself is still clearly physical. I don’t understand why people have such a problem accepting that drug dependencies are either neurological or somatic (or even both) but there’s literally still no such thing as a “non-physical drug dependency”. That’s a pretty contradictory notion. I mean somebody can say what they want about the symptoms themselves but the dependence.. like the actual dependence is ALWAYS physical and that’s an inescapable fact. So this is clearly a misnomer.
Also not that it really matters and it’s certainly not a competition but.. Those “opioid withdrawal symptoms“ you listed sound like some pretty rookie shit to me. I’ve had weed withdrawals that make those symptoms you listed look like a freaking trip to Disneyland. And I mean restless leg syndrome? Really? I mean come on lol, I know RLS sucks but people get that from SO many drugs. You do know RLS is mostly correlated with deficient dopamine levels right? Also no offense but virtually everything you said here pretty much goes without saying, it’s kind of just a reiteration of the same stuff people have said for a while now but it still doesn’t reconcile how the dependence is not physical. It’s still physical. We already know the presentation symptoms between these drugs. Like we know dude lol but come on you can’t really think that actually changes this issue. We don’t have to be experts to discern this. And I would gladly change or look into changing the “psychological dependence” article to a title such as “neurological dependence” but the terminology as of now makes no sense and is CLEARLY outdated. And yes credentialed people have pointed this out. But either way it’s a pretty obvious thing. I mean the title and what it implies is like straight out of the 80/90s or something. I even kinda wish there was even room for debate on this topic there really isn’t.. Sorry but there’s just no debatable angles to this. All drug dependencies are physical. There’s no way around that. Dexedream (talk) 16:43, 29 July 2023 (UTC)[reply]
If you want to conflate the two, that’s your prerogative. Everyone else in the world is still going to make the distinction. Seppi333 (Insert ) 20:36, 3 August 2023 (UTC)[reply]
Everyone else in the world? Nobody believes neurological doesn’t mean physical Dexedream (talk) 18:13, 4 August 2023 (UTC)[reply]
People think “psychological dependence” means a fictive craving or just a mental desire. They don’t realize that it has neurological foundations and if they did they would admit that it’s physical, which it is. This is one of the things that’s not debatable. Dexedream (talk) 18:18, 4 August 2023 (UTC)[reply]
It doesn't matter what your opinion is. Wikipedia articles are based on reliable sources that meet WP:MEDRS criteria. If you want to disseminate your personal opinion, you should do that in your own blog or somewhere else, and not infiltrate into every medical article pushing your personal opinion. --WikiLinuz {talk} 18:24, 4 August 2023 (UTC)[reply]

This article needs mentions and definitions of "super meth" and "P2P meth"

"Super meth" and "P2P meth" are getting a lot of discussion in the popular press lately but are not mentioned here. Could someone please add some information? Mondebleu (talk) 20:39, 13 November 2023 (UTC)[reply]

See History_and_culture_of_substituted_amphetamines#Illegal_synthesis. --WikiLinuz (talk) 01:54, 14 November 2023 (UTC)[reply]

Death from Overdose

This section is well reference by many reliable sources including the CDC. Reknihtdivad (talk) 13:48, 22 November 2023 (UTC)[reply]

reliasmedia.com, nchrc.org, amegroups.org, consultant360.com, and chooser.crossref.org are not reliable sources.
Interpreting WP:PRIMARY sources (such as stats, invidual case reports, etc.) is WP:OR. Overdose information should be sourced from WP:SECONDARY sources that meet WP:MEDRS criteria. --WikiLinuz (talk) 19:04, 22 November 2023 (UTC)[reply]
Thank you for your help. That is greatly appreciated. Reknihtdivad (talk) 20:10, 22 November 2023 (UTC)[reply]

@WikiLinuz:Reknihtdivad (talk) 15:09, 22 November 2023 (UTC)[reply]

Methamphetamine overdose deaths often involves polydrug abuse, involving various drug classes, not just methamphetamine. This nuance should be included if we write a section on overdose deaths. It should be tailored to incidents of only methamphetamine overdose. --WikiLinuz (talk) 13:16, 27 November 2023 (UTC)[reply]

Although these statistics are reported as deaths involving a particular drug, I made that change, the CDC implies that these numbers represent the number of deaths with a particular drug, at least with opiates. See Understanding the Opiate Epidemic. https://www.cdc.gov/opioids/basics/epidemic.html
It might be that opiates are perceived to be more lethal than methamphetamine or cocaine which is probably true. Reknihtdivad (talk) 03:40, 28 November 2023 (UTC)[reply]

Semi-protected edit request on 7 March 2024

Change “Addiction liability” from Very High to Moderate (10-15%).

There is no evidence that Methamphetamine addiction potential is ‘very high’, and there is no source linked to back up that claim on this page.

Meanwhile, studies show Methamphetamine to have moderate addiction potential, 10-15%, which is the same addiction liability as Alcohol which has “Moderate (10-15%)” on its wiki page.

This information should also be added to the pharmacology section on the page.

Here is a link to one such study that shows Methamphetamine’s 10-15% addiction liability:

https://www.researchgate.net/publication/232545123_Comparative_Epidemiology_of_Dependence_on_Tobacco_Alcohol_Controlled_Substances_and_Inhalants_Basic_Findings_From_the_National_Comorbidity_Survey

Thank you. 24.5.117.157 (talk) 22:06, 7 March 2024 (UTC)[reply]

 Not done: Methamphetamine have established addiction liability. Methamphetamine#Addictive. That linked paper doesn't say methamphetamine has 10-15% addiction liability. --WikiLinuz (talk) 00:05, 8 March 2024 (UTC)[reply]