Talk:Lentigo maligna
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Article categorization
This article was initially categorized based on scheme outlined at WP:DERM:CAT. kilbad (talk) 22:34, 30 May 2009 (UTC)
Comments
At the end of this article, treatment with Imiquimod is quite unconditionally recommended in the sentence:
"Considering the very poor cure rate with standard excision, it might not be a bad idea to follow up all surgical excisions with topical imiquimod treatments."
This use is off label. Lentigo maligna is not mentioned in the documentation from the manufacturer nor is it mentioned in registration documentation. I tried to go through the literature in the subject, which gives a very positive view of the treatment, but consiste of mostly case reports and very little controlled studies with defined end points, and short follow-up.
Therefore, I feel that this statement should be less unconditional and a source should be given. Also, I feel that Wikipedia should not make recommendations about medical treatment, and the sentence should be reformulated not to be a recommendation.
The following is the conclusion of a review:
"Although imiquimod clearly has an effect on LM, this analysis of available studies has helped to identify concerns about its use. Without controlled evidence and prolonged follow up, the use of imiquimod for LM must still be considered experimental."
The reference to this review [1] could be given as source for this treatment of LM. Lave (talk) 19:38, 7 January 2009 (UTC)
- ^ Rajpar SF, Marsden JR (2006). "Imiquimod in the treatment of lentigo maligna". Br. J. Dermatol. 155 (4): 653–6. doi:10.1111/j.1365-2133.2006.07476.x. PMID 16965411.
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What is time for progression to lentigo malgna melanoma?
Anyone suspected of having this would, I am sure, like to know what the time for progression to melanoma is, and at different ages. If the progression takes 15 years for say 90% of instances a person aged 60 might take a very different approach compared to if the progrssion takes only 5 years for 50% of cases. But does progression take different lengths of time at different ages, eg because of differences in hormone levels at different ages? Does anyone know of any studies? dinghy (talk) 02:06, 2 November 2011 (UTC)