Talk:Inflammatory cytokine

Drafting a New Lead Section and Proposed Changes

Proinflammatory cytokines are a specific category of cytokines that are important in cell signaling. These cytokines act to make a disease worse, contrasted to those that are anti-inflammatory, which promote healing and reduce inflammation. Functions include neutralizing antibodies, serving as soluble receptors and receptor antagonists, and inhibiting proteases. PMID 26788465. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help).Proinflammatory cytokines arise from genes that code for the translation of small mediator molecules that induce a response after upregulation. For example, chemokines are a class of genes that are proinflammatory. IL-1, TNF, and chemokines are examples of proinflammatory cytokines.

Proinflammatory cytokines work with other important molecules from the immune system, such as neutrophils and leukocytes, in generating an immune response. This proinflammatory cytokine-mediated inflammation generates a collection of gene products when there are triggers that notice the presence of a foreign body. However, excessive amounts of proinflammatory cytokines have been shown to cause detrimental effects, causing chronic systemic elevations in the body. Scarpioni, Roberto (2016). "Secondary amyloidosis in autoinflammatory diseases and the role of inflammation in renal damage". World Journal of Nephrology. 5 (1): 66. doi:10.5527/wjn.v5.i1.66.{{cite journal}}: CS1 maint: unflagged free DOI (link)A lack of regulation in the release of these cytokines has been linked to different diseases, such as atherosclerosis and cancers. There are further implications that misregulation of proinflammatory cytokines is also linked to depression and other neurologically related effects to the body. PMID 26631274. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help). Aging and exercise also plays a role in the amount of inflammation produced through the release of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α)Sallam, Nada; Laher, Ismail (2016). "Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases". Oxidative Medicine and Cellular Longevity. 2016: 1–32. doi:10.1155/2016/7239639.{{cite journal}}: CS1 maint: unflagged free DOI (link) Recent therapies reveal the method of blocking proinflammatory cytokines as a response towards the attack of these cytokines against our own bodies.

It is important that the regulation between proinflammatory and anti-inflammatory cytokines stay balanced, as that could alter one's susceptibility to a disease.

Proposed Changes: I plan to add more information in the "Clinical implications" section about:

• role in different cancers
• cardiovasular diseases (atherosclerosis)
• depression
• causing neuroinflammation and its relation to the microglia
• (maybe adding an entire section about diseases)

Additional things to possibly add:

• Regulation of Proinflammatory cytokines
• Anti-inflammatory cytokines and pro inflammatory cytokines working together
• More detailed description about their functions
• relation to Inflammatory Bowel Disease
• Graft vs Host diseases
• Methods of blocking proinflammatory cytokines that cause disease

Immcarle2 (talk) 06:58, 9 February 2016 (UTC) Immcarle2 (talk) 06:54, 5 February 2016 (UTC)

Helpful Review Articles about proinflammatory cytokines

These are updated articles that are secondary sources:

Scarpioni, Roberto; Ricardi, Marco; Albertazzi, Vittorio (2016-01-06). "Secondary amyloidosis in autoinflammatory diseases and the role of inflammation in renal damage". World Journal of Nephrology 5 (1): 66–75. doi:10.5527/wjn.v5.i1.66. ISSN 2220-6124. PMC 4707170. PMID 26788465.

Allen, Clint T.; Clavijo, Paul E.; Van Waes, Carter; Chen, Zhong (2015-12-09). "Anti-Tumor Immunity in Head and Neck Cancer: Understanding the Evidence, How Tumors Escape and Immunotherapeutic Approaches". Cancers 7 (4): 2397–2414. doi:10.3390/cancers7040900. PMC 4695900. PMID 26690220.

Sallam, Nada; Laher, Ismail (2015-12-28). "Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases". Oxidative Medicine and Cellular Longevity 2016: 1–32. doi:10.1155/2016/7239639. PMC 4707375. PMID 26823952.

Slocum, C.; Kramer, C.; Genco, C. A. (2016-01-21). "Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammation and atherosclerosis". Journal of Internal Medicine. doi:10.1111/joim.12476. ISSN 1365-2796. PMID 26791914.

Haapakoski, Rita; Ebmeier, Klaus P.; Alenius, Harri; Kivimäki, Mika (2016-04-03). "Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances". Progress in Neuro-Psychopharmacology and Biological Psychiatry 66: 63–72. doi:10.1016/j.pnpbp.2015.11.012.

Su, P.; Zhang, J.; Wang, D.; Zhao, F.; Cao, Z.; Aschner, M.; Luo, W. "The role of autophagy in modulation of neuroinflammation in microglia". Neuroscience. doi:10.1016/j.neuroscience.2016.01.035. — Preceding unsigned comment added by Immcarle2 (talk • contribs) 06:06, 5 February 2016 (UTC)

Helpful articles about proinflammatory cytokines

As a part of my Immunology class, we are choosing an article to expand and provide more information. This article appears to be a starter article that is important within a larger topic of cell signaling. There are many cytokines that send different signals throughout the body, but these specific ones are important in promoting an immune response. Because this article is barely starting to develop, I compiled a bibliography of relevant articles that relate to the study of proinflammatory cytokines:

Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock.

Dinarello, Charles A. (1997-12-01). "Proinflammatory and Anti-inflammatory Cytokines as Mediators in the Pathogenesis of Septic Shock". Chest 112 (6, Supplement): 321S–329S. doi:10.1378/chest.112.6_Supplement.321S.

Blocking of proinflammatory cytokines in cancer.

Dinarello, Charles A. (2006-09-01). "The paradox of pro-inflammatory cytokines in cancer". Cancer Metastasis Reviews 25 (3): 307–313. doi:10.1007/s10555-006-9000-8. ISSN 0167-7659. PMID 17029030.

Anti-cytokine therapy for those with Crohn's Disease

Hinoki, Akinari; Yoshimura, Kazunori; Fujita, Keiko; Akita, Masumi; Ikeda, Rie; Nagashima, Masabumi; Nomura, Masahiko; Satomi, Akira (2006-11-01). "Suppression of proinflammatory cytokine production in macrophages by lansoprazole". Pediatric Surgery International 22 (11): 915–923. doi:10.1007/s00383-006-1767-8. ISSN 0179-0358. PMID 16932910.

Role of cytokines in Inflammatory Bowel Disease

Sanchez-Muñoz, Fausto; Dominguez-Lopez, Aaron; Yamamoto-Furusho, Jesus K (2008-07-21). "Role of cytokines in inflammatory bowel disease". World Journal of Gastroenterology : WJG 14 (27): 4280–4288. doi:10.3748/wjg.14.4280. ISSN 1007-9327. PMC 2731177. PMID 18666314.

Proinflammatory cytokines and its impact on Type 2 Diabetes Tuttle, Hillary A.; Davis-Gorman, Grace; Goldman, Steve; Copeland, Jack G.; McDonagh, Paul F. (2004-12-01). "Proinflammatory cytokines are increased in type 2 diabetic women with cardiovascular disease". Journal of Diabetes and Its Complications 18 (6): 343–351. doi:10.1016/S1056-8727(03)00088-6. ISSN 1056-8727. PMID 15531184.

Guest, Christopher B.; Park, Min J.; Johnson, Daniel R.; Freund, Gregory G. (2008-01-01). "The implication of proinflammatory cytokines in type 2 diabetes". Frontiers in Bioscience: A Journal and Virtual Library 13: 5187–5194. ISSN 1093-9946. PMID 18508580.

Both Pro and anti-inflammatory properties of cytokine-interleukin 6

Scheller, Jürgen; Chalaris, Athena; Schmidt-Arras, Dirk; Rose-John, Stefan (2011-05-01). "The pro- and anti-inflammatory properties of the cytokine interleukin-6". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. Including the Special Section: 11th European Symposium on Calcium 1813 (5): 878–888. doi:10.1016/j.bbamcr.2011.01.034.

Immcarle2 (talk) 21:14, 2 February 2016 (UTC)

copyediting and attention by content expert needed

The article is on a really poor level regarding content, structure and style.

It was apparently written by people inexperienced in writing in general, lack of content knowledge, dare-I-say expertise (even basic basic physiology like what are white blood cells), and inexperienced in WP editing. Haven´t checked for copyvios, but the text to me suggests really uncritical lifting and paraphrasing from biomed journals.

content examples:

• No definition section- a problem in 80% of science articles...
• entirely human focus (very primitive)
• editorializing.
• WP articles must be balanced ( here: just negative impacts of Proinflammatory cytokineare mentioned)

formal examples:

• someone changed the page title to singular, ok, but didnt do teh work in teh body of teh text (not thorough, not smart or lazy)
• use of the term patient (must not be used).
• excessive wordiness (WP should clarify and not complicate/hype things)

references:

• no reviews used
• as much as possible open access refs should be used. otherwise how can anyone but a member of a university check the veracity of a claim?

Ive just noticed, that Carleton College is unleashing its brains on immunology articles again and I hope that rather than creating new bad articles existing immunology articles are getting a thorough makeover and maintenance check! (like microbioal symbiosis and immunity) --Wuerzele (talk) 08:52, 16 February 2017 (UTC)

Agreed that this article needs a lot of copyedit. I made an initial stab at the lead. Boghog (talk) 12:04, 16 February 2017 (UTC)

Boghog thanks.--Wuerzele (talk) 21:03, 16 February 2017 (UTC)

Wiki Education assignment: Immunology

This article is currently the subject of a Wiki Education Foundation-supported course assignment, between 29 January 2024 and 14 May 2024. Further details are available on the course page. Student editor(s): Kmeehan0214 (article contribs). Peer reviewers: Echall.su.

— Assignment last updated by Poisonpearl (talk) 06:55, 17 March 2024 (UTC)