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According to Elks et al.[1] and Chopra et al.[2] Demeclocycline is NOT a semisynthetic drug. Instead it is produced naturally by a genetically modified strain of Streptomyces. The author of the cited review, I. Chopra, used to work for one of the leading manufacturers of this compound, even more as a specialist for tetracyclines, who published many more papers on this topic. He must have known this. Same is also supported by the DailyMed entry.[3] (I updated the existing link.) J. M. Hall,[4] however who just made a short lexicon entry, most likely mistook her statement form the fact that the drug is used for producing semisynthetic derivatives like Minocycline and Doxycycline. The entry in Dorland's Medical Dictionary[5] is not available anymore. Thus, I took off the latter two references, which obviously are misleading and simply removed the statement that Demeclocycline is semisynthetic.--Asigler (talk) 22:20, 11 October 2018 (UTC)[reply]
^Chopra, I.; Hawkey, P. M.; Hinton, M. (1992). "Tetracyclines, molecular and clinical aspects". J. Antimicrob. Chemother. 29 (3): 245–277. doi:10.1093/jac/29.3.245.
