Talk:Colistin

Klebsiella pneumoniae¹ is another example of Gram negative bacteria which are resistant to all antibiotics except Colistin. 1. http://health.yahoo.net/experts/dayinhealth/antibiotic-superbugs-crkp-mrsa-risk — Preceding unsigned comment added by Emm21 (talk • contribs) 05:17, 8 April 2011 (UTC)

The statement "these poly cationic regions interact with the bacterial outer membrane, by displacing bacterial counter ions in the lipopolysaccharide. hydrophobic/hydrophillic regions interact with the cytoplasmic membrane just like a detergent, solubilizing the membrane in an aqueous environment." at the very least needs a reference. The one reference I have is pretty authoritative on antimicrobials and says that colistin act at the inner membrane, so the above statement appears wrong. (see p855 and 856 of "antimicrobial agents" edited by Andre Bryskier (2005)

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— Preceding unsigned comment added by Ambro17 (talk • contribs) 18:01, 12 January 2011 (UTC)

Help! I've messed up the reference and don't know how to fix it. Possibly, the problem is due to not having a page number on the Emerg Infec Dis citation, which is an online journal at http://www.cdc.gov/ncidod/eid/vol9no8/03-0052.htm Hcberkowitz 00:22, 21 March 2007 (UTC)

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Sorted. Pubmed is a good tool for finding references. 1/5/07 62.49.184.67 16:34, 1 May 2007 (UTC)

Resistance threshholds

2 of the resistances are reported in mg/l while 1 is reported in mg/ml. I believe the last one is the wrong one, does anyone know for sure? Also, I usually see antibiotic concentrations reported in micrograms/ml rather than mg/l. Is there a standard for these articles?Koifishkid (talk) 21:50, 6 March 2012 (UTC)

is the colistin figure correct?

Is this figure of colistin correct? In both colistin A and colistin B, there's a methyl attached to the 5th carbon after the carboxyl... The figure indicates that this is attached to the 4th carbon.--98.70.142.212 (talk) 22:30, 4 February 2013 (UTC)

The chemical structure seems to me to match those given at the various links in the infobox. But maybe I'm just missing it. Can you be more specific about which group you're talking about? Is it the amide at the far left of File:Colistin.svg? ChemNerd (talk) 13:57, 5 February 2013 (UTC)

I agree. The tail looks wrong in the chair conformational structure. I believe it is a 1-methyl-hexane connected to the carboxyl group and not a 2-methyl hexane. — Preceding unsigned comment added by 108.174.108.127 (talk) 00:57, 19 May 2021 (UTC)

Polymyxin B shows two forms, B1 and B2, that differ in exactly the same way. Perhaps this applies to colistin, too. --Ben (talk) 08:18, 19 May 2021 (UTC)

reistance cutoff

it might be appropriate to refer to the EUCAST breakpoints (publicly available on the EUCAST website) rather than individual european standards, as EUCAST standards are supposed to be pan-european. 137.204.127.13 (talk) 15:28, 10 December 2018 (UTC)