Talk:Clenbuterol

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Celnbuterol is also gaining attention as a weight-loss pill for the elite crowd. My understanding is that it is - as one might expect - dangerous for human consumption. Wanted to run this by the discussion board before posting the info, as I don't know the exact rules on rumors and gossip going on Wikipedia. --Spesek 02:04, 12 October 2006 (UTC)[reply]


I have also heard of that. Does anyone have any information on this?

Struck passage

Is there a reason the text 'Clenbuterol is also a sympathomimetic in the peripheral nervous system.' is struck rather than simply not being there? 71.227.168.121 (talk) 00:56, 1 July 2011 (UTC)[reply]


Heart problems

I've been hearing about a link between clenbuterol use and cardiac myopathy (which has been explained to me as the thickening of the heart muscle-- not good)... but there's nothing in the article about this link. Web searches uncover lots of articles about clenbuterol and the heart (mostly in medical language that I don't understand). Seems like this article should have some mention of that, somewhere? Can someone with more knowledge of this (I'm not a doctor!) summarize and amend the article? 69.154.23.143


Ok, I suck at this editing stuff... But I am a medical student and have done research into clenbuterol and other doping agents. First, cardiac myopathy does not mean thickening of heart muscle specifically, it means diseased heart muscle. The disease can be one of many, as you will see if you search for cardiomyopathy here on Wiki or anywhere else. There is actually evidence in animal models that beta2-receptor agonists (such as clenbuterol) has a stimulatory effect on the healing of cardiac myopathys caused by ischemia [1] (loss of blood supply to heart wall, as in a heart attack).

Second, of course the use of clenbuterol can be dangerous... if it's not used correctly. That means keeping the right dosage, and timing of doses. Clenbuterol has a very long half-life, which means it will stay in the body for a long time before being excreted or metabolized. This in turn means that doses can't be taken to close to each other, or overdosing may occur. Now, overdosing clenbuterol is very bad indeed. I read in a thread downstream from this one someone asking if he should take 20 mg of clenbuterol. I seriously hope he meant 20 mcg, since 20 mg may very well have killed him. Overdosing is the greatest risk associated with clenbuterol use, since overdosing causes tachychardia and hypokalemia ([2](extremely fast heartbeats and dangerously low levels of potassium) which among people with an underlying disease can lead to heart attacks or strokes. —Preceding unsigned comment added by Dr Mixe (talk • contribs) 00:46, 24 January 2009 (UTC)[reply]

References

  1. ^ J Pharmacol Exp Ther. 2006 May;317(2):553-61. Epub 2006 Jan 18
  2. ^ J Med Toxicol. 2007 Jun;3(2):56-60.Click here to read

Neutrality?

I challenged the neutrality of the first sentence that says Clenbuterol is not a steroid but is thought of as one due to its 'abuse' in bodybuilding. Who, exactly, is it that thinks of Clenbuterol as a steroid? It's a bronchodialator that is used in bodybuilding for it's thermogenic properties to increase metabolism and shed fat before a subjective modeling contest. And who defines the word 'abuse'? If someone safely and effectively uses this drug to lose fat, do you define that as abuse? Many drugs that were developed and sent to market for purpose A were later found to work perfectly for purpose B. Look up Buproprion HCL.

As for the above posted question; Clenbuterol was originally developed for human consumption. However, when Salbutamol was developed it was a better drug for the purpose of bronchodialation. It could be delivered in an atomized form and it had a much much shorter half life than its chemical cousin, Clenbuterol (1.6 hours vs. 36 hours). I posted a link at the bottom of the Clenbuterol page that shows the doses at which athletes safely use clenbuterol to burn fat. BPBomber 16:12, 16 January 2007 (UTC)[reply]

The current page is somewhat contradictory. On the one hand, clenbuterol is used to reduce weight in humans, on the other hand, it is used to increase weight in animals. Can someone resolve this, please?

-- it's used to burn fat, not reduce weight. —Preceding unsigned comment added by 204.193.129.239 (talk) 23:47, 6 December 2007 (UTC)[reply]

Yes, it is used as a bronchodilator and as a thermogenic agent to burn fat and raise metabolism just like Ephedrine based diet pills. —Preceding unsigned comment added by 64.131.233.109 (talk) 21:05, 12 July 2008 (UTC)[reply]


I looked on the official websites at NIH and the Mayo Clinic and did not find anything on the Mayo Clinic website. There must be a blip on the NIH website, but I could not find it. This drug is a bronchodilator. It has the appearance (not literal) of epinephrine and will raise the blood pressure. If you lose any amount of weight without the drug, you will lose fat (unless your body has NO fat). If it is like ephedrine, then it resembles caffeine and will increase the heart rate. I cannot find anything ( no reference) scientific about this drug. Someone needs to do some serious research about this, write about it and provide current references. Warren —Preceding unsigned comment added by 71.140.91.198 (talk) 05:46, 30 September 2010 (UTC)[reply]

I appologize. It should have said that it resembles epinephrine and not ephedrine. Warren —Preceding unsigned comment added by 71.140.91.198 (talk) 06:07, 30 September 2010 (UTC)[reply]

dosage

How often do you take a 20 mg dosage? Do you take with water? In the morning? ect. I ordered some on line and the instruction came in a different language!!!

  • This is not a discussion forum for clenbuterol dosage.GetAnabolics 20:09, 12 March 2007 (UTC)[reply]


Clenbuterol

I believe this sentence is not accurate: Clenbuterol is often mistaken for a steroid because of its illicit use in athletics. I suggest the following modification: ...often mistaken for an anabolic androgenic steroid....GetAnabolics 20:09, 12 March 2007 (UTC)[reply]


please please tell me you didn't take 20 mg? You meant 20 mcg, right? Cause otherwise you're dead. It's all in the numbers. Micrograms should never be confused with milligrams. —Preceding unsigned comment added by Dr Mixe (talk • contribs) 00:51, 24 January 2009 (UTC)[reply]

Recreational use

What about recreational use? I've heard it's taken by junkies... --Alexander Ivashkin 19:55, 23 May 2007 (UTC) The entry does not address whether it is legal to have or not, just weasel words about it not being approved.[reply]

It's legal only by perscription in most countries, illegal in most nanny states however. As far as recreational use goes, if anyone used it they'd use it once then never touch it again as it really doesn't provide any high or euphoric feeling, it actually feels amazingly shit. I couldn't picture anyone using it for fun, that's for sure. 124.179.19.254 (talk) 15:49, 15 July 2011 (UTC)[reply]

Fair use rationale for Image:Clenbuterol.png

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BetacommandBot (talk) 20:33, 13 February 2008 (UTC)[reply]

Contradiction

In the Effects and Dosage section it says this:

It increases the rate at which fats are metabolized, simultaneously increasing the body's BMR.

Human Use:

It is commonly used as a slimming aid despite lack of sufficient clinical evidence supporting such use[2].

If it increases the basal metabolic rate then it surely must work as a slimming aid? 78.82.141.241 (talk) 18:30, 25 March 2010 (UTC)[reply]

This section has one reference and it is a blog. I didn't see anything about the drug in it. I may have missed it or it is from a long ago date. The rest of the paragraph has no reference whatsoever. I do not see any medical or scientific reference at all for this drug. There needs to be more 'accurate' information about it and some reasonable references for it. Warren —Preceding unsigned comment added by 71.140.91.198 (talk) 05:16, 30 September 2010 (UTC)[reply]

Alberto Contador

I wonder if this page is the right place to discuss current doping allegations on Alberto Contador. —Preceding unsigned comment added by Juancdelalamo (talk • contribs) 00:49, 30 September 2010 (UTC)[reply]

Not sure if it is, but reporting his defenses as widely-accepted fact, and then citing to his press report, violates rules of neutrality. I've edited, but feel free to delete the whole reference. —Preceding unsigned comment added by 96.241.14.32 (talk) 01:45, 30 September 2010 (UTC)[reply]

It may be appropriate to add that the Contador case is under investigation in the Human Use section but I am not the person maintaining this article and would not dream of adding it. It is appropriate to discuss what seems to be a contradiction here. The WADA classifies it as steroidal (anabolic as opposed to catabolic) drug whereas what is written here and other places does not seem to indicate that it has that effect in humans. It seems have it in some (non-human) animals. Elevating your BMR and losing fat does not necessarily equate to increasing muscle mass. Where is the proof it has an anabolic effect in humans? But most of its role in doping probably belongs in the discussion section of "Use of performance enhancing drugs" or some other page rather than here. I may wander over there and ask for some clarification. There is a lot FUD on this one right now. Primarily a lot more research needs to be done to specify for example whether the increased aerobic capacity is due solely to improved breathing or if there is more to it than that. Also please add more to the Overdosage section as it becomes available Oh yes, what is the legal threshold as given by the WADA before you are marked positive? How many FPs are there at that threshold? I am not finding that information any place. If they set the limits too low how many FPs do they have? You need to provide a pointer to the information that is in another page if it is is not relevant to the discussion here. hhhobbit (talk) 16:33, 5 October 2010 (UTC)[reply]

It is commonly used as a slimming aid despite lack of sufficient clinical testing either supporting or negating such use.

This section confuses me. Whilst prima facie it is just stating there's no clinical testing (which I doubt), the way it is phrased implies that it is debatable whether it is an effective means of losing fat. It has been used by cattle farmers to create very lean stock with extremely low fat content and has been for decades, and as far as data on it's usage, whilst it'd all be personal research, you can find thousands of day by day reports of it's usage by gym junkies and body builders.

It's an extensively documented drug as far as it's effectiveness in weight loss goes, so I find this article quite shocking in it's lack of information while researching it's use. I usually turn to wiki first, but tbh this has less information than even randomly generated pages for search engine hooking sites. :/ Could someone with more wiki skeelz than I please fix this shit up? 124.179.19.254 (talk) 15:55, 15 July 2011 (UTC)[reply]

Muscular Development source

I'm rather suspicious of this source. While it is plausible the writer is a reliable source who happens to be writing with a sexual hype, it really sounds promotional and disingenuous.

  • Carlon M. Colker, MD (9 September 2006). "Clenbuterol". Muscular Development. For quite a few years now, clenbuterol has been the drug of choice, especially among fitness chicks. I remember how they would all grub for "clen" around the gym. I mean coast to coast, at nearly every hardcore gym where I'd train, these chicks were like little junkies (and so many still are). Showing them some clen was like showing crack to a crackhead. I've known guys who traded clen for locker room oral sex from fitness piggies.

I have removed an anchor link that goes nowhere on the referred page, making me suspicious of affliate linking. I'd like to gong the entire sentence if no one objects; however, I imagine we could keep it if someone has a better source for the drug's popularity specifically in the women's gym and/or bodybuilder scene. / edg ☺ ☭ 16:59, 31 January 2014 (UTC)[reply]

Removed / edg ☺ ☭ 21:05, 5 February 2014 (UTC)[reply]

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ALS trial

Write about the potential for slowing ALS progression. 46.131.61.209 (talk) 17:13, 30 June 2022 (UTC)[reply]

Anabolic effects of clenbuterol

The article state that clenbuterol does not have anabolc effects. This seems contrary to the evidence on the matter.

https://onlinelibrary.wiley.com/doi/10.1002/mus.10092 https://www.ahajournals.org/doi/full/10.1161/01.cir.92.9.483 https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-7-320 2001:700:1500:D125:9EB:BB61:FE56:D791 (talk) 10:20, 1 November 2023 (UTC)[reply]

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