Talk:Bevacizumab

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External Links to Specific Trials

The listing of specific trials that involve the drug, as is being done on this page, is misleading and seems to convey an impression that these are the "selected" trials. I would recommend a more general link to all avastin http://clinicaltrials.gov/ct2/results?term=&recr=Open&rslt=&type=&cond=&intr=bevacizumab&outc=&lead=&spons=&id=&state1=&cntry1=&state2=&cntry2=&state3=&cntry3=&locn=&gndr=&rcv_s=&rcv_e=&lup_s=&lup_e= trials in ClinicalTrials.gov. Quietvillager (talk) 16:26, 1 October 2009 (UTC)[reply]

Contradiction

Does Bevacizumab prolong life or doesn't it? The "clinical use" section says

The panel expressed concern that data from the clinical trial did not show any increase in quality of life or prolonging of life for patients

whereas the "costs" section has

Doctors and editorials have criticized the high cost, for a drug that doesn't cure cancer but only prolongs life

--Commutator (talk) 13:52, 26 September 2008 (UTC)[reply]

Bevacizumab has been shown to prolong survival in people with colorectal cancer and certain types of lung cancer. In people with breast cancer, it prolongs progression-free survival, but not overall survival. Fvasconcellos (t·c) 11:18, 29 November 2008 (UTC)[reply]

Mechanism

It is now believed that Avastin does not block angiogenesis, but actually increases it. This then stabilises the tumour blood vessels, and allows other chemotherapy agents better access to the tumour site, increasing their efficacy. —Preceding unsigned comment added by 91.110.239.180 (talk) 12:08, 4 May 2008 (UTC)[reply]

What is your reference on this? 128.104.69.45 (talk) 15:11, 25 August 2008 (UTC)[reply]

Bevacizumab Chemical Formula

I am interested in the exact english version (name) la of Bevacizumab. So, if somebody knows it, I would appreciate his-her help! — Preceding unsigned comment added by 195.134.99.82 (talk)

The "zumab" part means humanized monoclonal antibody. The actual antibody may not have another name except for tradenames like Avastin and a sequence.Rbcody (talk) 13:23, 27 April 2008 (UTC)[reply]

Clinical Trials

I'd like some information on the clinical trials and success of Bevacizumab, or at least a link to some relevant scientific papers. Also, some information on the development of the drug would be useful. This is a much more interesting reference: http://www.wjgnet.com/1007-9327/13/5857.asp. It's a review on targeting angiogenesis as a treatment for cancer. —Preceding unsigned comment added by Sartchy (talk • contribs) 01:42, 21 November 2007 (UTC)[reply]

Latest Information on the CATT Study of Avastin vs Lucentis for Wet AMD

I've tried to update the external link to the latest information from my web Journal on the CATT Study, but the revert bot won't accept it.

For those of you interested in the latest information on the CATT Study, please take a look at my web Journal:

CATT Study Update 6: Official Announcement of Trial Start from NEI

```Irv Arons —Preceding unsigned comment added by Iarons (talk • contribs) 22:58, 28 February 2008 (UTC)[reply]

Which VEGF

Could we clarify if it binds only to VEGF-A (like Ranibizumab) or if it binds to more than one of VEGF ? Rod57 (talk) 02:35, 14 December 2008 (UTC)[reply]

It's anti-VEGF-A. "VEGF" is still often used to refer to VEGF-A, so most sources just say bevacizumab is an "anti-VEGF antibody". I'll clarify this in the article and add some references. Fvasconcellos (t·c) 15:41, 14 December 2008 (UTC)[reply]
Thanks. I see you updated the drugbox. I've updated the intro to match (after checking ref 1). Rod57 (talk) 15:43, 12 December 2009 (UTC)[reply]

Should clarify that bevacizumab blocks BINDING of VEGF-A to a particular VEGF receptor isotype, and identify the isotype. —Preceding unsigned comment added by 70.182.58.2 (talk) 22:21, 26 January 2010 (UTC)[reply]

Corruption Affair

There is an ongoing corruption affair in Serbia with 8 people arrested for taking and giving bribes in collusion with several pharmaceutical firms to increase the use of cancer medication, prominently featuring Avastine.

Please add more info:

sources: english more info: serbian —Preceding unsigned comment added by 91.61.43.56 (talk) 00:16, 18 July 2010 (UTC)[reply]

FDA rejects Avastin for Breast Cancer

I'm not sure where in the article to mention this but the breast cancer info needs updating.
See:

Andrew Pollack (December 16, 2010). "F.D.A. Rejects Use of Drug in Cases of Breast Cancer". NY Times. Retrieved 2010-12-16.

Here is the citation ready to add to the article:
<ref name="Breast Cancer">{{cite news | url=http://www.nytimes.com/2010/12/17/health/policy/17drug.html |title=F.D.A. Rejects Use of Drug in Cases of Breast Cancer|newspaper=NY Times |date=December 16, 2010|accessdate=2010-12-16|author=Andrew Pollack}}</ref>
--Javaweb (talk) 17:26, 17 December 2010 (UTC)Javaweb Updated Avastin info from FDA: Avastin (bevacizumab) Information http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm193900.htm[reply]


http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm237172.htm "FDA begins process to remove breast cancer indication from Avastin label Drug not shown to be safe and effective in breast cancer patients."
In any case, the drug will still be available for the next few months while Genentech appeals the decision. This has no affect on its use in non-breast cancer treatment. --Javaweb (talk) 17:51, 17 December 2010 (UTC)Javaweb User_talk:Javaweb/Avastin has a suggested replacement for the Indications section. I would like some review before putting this in the article because it is important to get this right. Most of the changes are adding subheads for each of the cancers, and adding the new info on breast cancer.--Javaweb (talk) 20:26, 17 December 2010 (UTC)Javaweb[reply]

Is there a WikiProject for FDA idiocy? I think this is a prime example, along with things like the PPA fiasco, Meridia, etc. I'd like to see compilations of the number of people killed by the FDA bans or lesser actions or threats, compared to the minor risks of certain medications. Please let me know if anyone has taken this on. 71.203.125.108 (talk) 06:14, 28 December 2010 (UTC)[reply]

Hello, Very new to this but it appears the FDA has revoked the breast cancer indication from the drugs label: http://www.fda.gov/NewsEvents/Newsroom/UCM279485

no idea where or how to update this, but im sure you fine people do :) 86.8.172.242 (talk) 00:25, 19 November 2011 (UTC) — Preceding unsigned comment added by 86.8.172.242 (talk) 00:23, 19 November 2011 (UTC)[reply]

does avastin actually do anything good ?

as i understand the clinical data, for the first indication, avastin improves survival in colon cancer by a median of 5 months; in other cases, initial claims have not been backed up by subsequent trials. This raises a question: does avastin actually do anything at all ? If you take a step back, there are lots of drugs, and lots of clinical trials, so the probablility that one drug will eventually show some effect is high; the statisticians are suppposed to take care of this, but the history of clinical trials - again and again, drugs have smaller effects then thought - shows that for whatever reason, the stat people are not effective. so , it could be that avastin does absolutely nothing, except cause side effects and enrich genentech; —Preceding unsigned comment added by 75.67.134.245 (talk) 19:18, 26 December 2010 (UTC)[reply]

One problem is, the FDA sets things up to exclude many good medications. Thomas Eleri pointed out that medications are evaluated for FDA approval in a different process from how they are actually employed clincally. This leads to rejection of efficacious medications and inclusion of less effective ones, simply because inappropriate statistical techniques are employed. The FDA really needs to be wiped clean and reworked.71.203.125.108 (talk) 07:39, 28 December 2010 (UTC)[reply]

While I do not know its effects on cancer, as someone who received it as treatment for Best's Disease, it did improve my vision significantly and failing to receive an injection of it would cause my vision to degrade back to its previous level. ChristopherJN (talk) 00:03, 24 March 2014 (UTC)[reply]

Op-Ed on Avastin

Fredrick C. Tucker Jr. (May 24, 2011). "Drugs and Profits". New York Times. This is an op-ed so maybe not a good ref but may have information for the article. --Javaweb (talk) 18:15, 25 May 2011 (UTC)Javaweb[reply]

Genentech to Appeal Breast Cancer Ruling

ANDREW POLLACK (June 26, 2011). "Genentech to Appeal to F.D.A. for Breast Cancer Drug". New York Times.
--Javaweb (talk) 08:46, 27 June 2011 (UTC)Javaweb Reuters (June 29, 2011). "FDA panel rejects Avastin for breast cancer use". Chicago Tribune. {{cite news}}: |author= has generic name (help)[reply]
--Javaweb (talk) 21:56, 29 June 2011 (UTC)Javaweb[reply]

Canadian policies

http://www.healthzone.ca/health/newsfeatures/cancer/article/1089545--health-canada-reviewing-use-of-avastin-for-breast-cancer --Nbauman (talk) 05:15, 19 November 2011 (UTC)[reply]

FDA Revokes Avastin Approval

http://www.pbs.org/newshour/rundown/2011/11/fda-officially-revokes-avastin-approval.html

"There's simply no proof that the drug saves lives, FDA officials said Friday. FDA Commissioner Dr. Margaret Hamburg called it "a difficult decision.""

Just for breast cancer. "Even so, the drug won't be disappearing from the market. Avastin still has FDA approval for certain colon, lung, kidney and brain cancers."[1] MathewTownsend (talk) 16:58, 19 November 2011 (UTC)[reply]

External links modified

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Rearranged the Breast Cancer Approval Section

Hi, I've rearranged it so that it is in chronological order because I think it makes more sense this way. Red Fiona (talk) 19:47, 17 October 2018 (UTC)[reply]

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