Talk:Ankylosing spondylitis
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I have ankylosing spondylitis and have been put on Humira and methotrexate which has dramatically reduced my pain due to inflammation. I took every NSAID there is including Celebrex (Cox-2 drug). I didn’t see any mention of this newer medication. — Preceding unsigned comment added by 2601:5C6:C300:7A60:A421:15C9:A1BC:79C4 (talk) 21:36, 20 December 2020 (UTC)
AS
I was a Remicade patient for years when I had to take care of my ailing father with dementia I was put on Enbryl My new dr took me off of methotrexate which I didn't really notice a difference ...Ive had neck issues for years recently my right arm started hurting when I lifted weights I had to quit the pain was so severe Dr took xray Mri and after several months determined I had pinched nerves due to severe narrowing in my neck Ive had PT injections and nothing seems to help Now drs suggest Epidurals I do not want this but my pain gets so bad at nights ( lying down aggravates the nerves more) Im on Lyica on the meds for my AS and Tramadol and I have to take all of them in order to sleep. I do not know what to do Drs do not seem to want to help me only medicate me Im seeking help PLEASE — Preceding unsigned comment added by 107.167.230.25 (talk) 12:46, 4 April 2021 (UTC)
- Sorry to hear about that. Unfortunately, as per wp:forum this talk page is not the right place to ask questions about the topic itself. Instead, you may ask your question on the reference desk -- Datapass talk | contribs 12:45, 20 June 2021 (UTC)
"Combination of genetic and environmental factors"
ALL diseases known to man involve a combination of genetic and environmental factors, typically with one of those factors playing a greater role than the other. Why is this explanation being used so much these days in regard to diseases with unknown etiology? It does not aid in treatment, research or patient comfort. It essentially tells us nothing about the disease...other than that it is indeed a disease. Also, have any specific autoantibodies been shown to be strongly associated with ankylosing spondylitis? If not, then why is it being referred to as autoimmune. The autoimmune label is thrown around WAY too freely. Just because an inflammatory disease has an unknown (as of now) etiology, that doesn't make it autoimmune anymore than it makes it bacterial, viral or anything else. Cporosus1 (talk) 19:51, 5 December 2023 (UTC)
- Maybe you should take up your issues with "genetic and environmental factors" with these guys, who happened to write a giant paper answering your questions, and still used that phrase. This took me all of 5 seconds to find in a search btw, maybe do some due diligence instead of ranting?
- Basically, the exact etiology isn't known at this time, but it has extremely strong associations with HLA genes which encode for MHC proteins. Which implies that it is autoimmune. Feel free to read that link if you want a more detailed explanation. Just-a-can-of-beans (talk) 07:41, 12 February 2024 (UTC)