Talk:Aminopterin

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Untitled

According to the Free Online Dictionary by Farlex (http://www.thefreedictionary.com/aminopterin): aminopterin is "a folic acid antagonist, C19H20N8O5, used as an antineoplastic agent. It has been mainly replaced by methotrexate" and therefore, I think there should be some sort of explantion as to why it's redirected to methotrexate so as not to confuse the two molecules as being one in the same.

Folinic acid as treatment?

I've found a few links indicating Folinic acid can be used as a treatment because it is in a form that the body can use directly and is not blocked by the effects of the aminopterin. I am hesitant to add this info to the article as I have no real background in biochemistry. If someone with more background feels this information is suitable for inclusion, here are a couple links.

http://www.wyeth.ca/en/products/Product%20Monographs%20PDFs/Leucovorin_Jul15_2004%5B1%5D.pdf

http://www.annals.org/cgi/content/full/121/11/833

--Dfred 23:18, 23 March 2007 (UTC)[reply]

Folinic acid is indeed routinely used to counter the effects of methotrexate on healthy cells—this is known as "leucovorin rescue"—and as an antidote for MTX overdose. It has probably been studied for the same purpose with aminopterin, but I'm not a physician or vet, so I'd be hesitant to add this to the article as well. A PubMed search for "aminopterin" and "citrovorum" (name for folinic acid way back when) may produce some interesting articles. Fvasconcellos 13:20, 24 March 2007 (UTC)[reply]

Looks like this info made its way into the article. I have restructured what was there into a more logical format, but it still needs work... --Dfred 17:04, 25 March 2007 (UTC)[reply]

Mine this

Might want to mine this blog thead for aid in finding reliable sources for more info about the chemical, re Syntrex, etc. Syntrex study is cited in Wiki article with no mention that it owns some part of the rights to it. No time for me to do this now. Andyvphil 10:35, 16 April 2007 (UTC)[reply]

pronunciation?

I've always pronounced this as (uh-MEEN-o-TEAR-in), giving credence to its nitrogen and pterin character, but I've heard others (particular non-scientists) pronounce it (AM-in-OP-trin). Given that the p is supposed to be silent (like in pterodactyl) I would think the former is correct. Although I do realize language is plastic and we do of course pronounce the p in helicopter.Pdcook (talk) 18:51, 13 October 2009 (UTC)[reply]

Illogical as it may be, I've always heard it pronounced the latter way, as prescribed in most dictionaries. Fvasconcellos (t·c) 19:15, 13 October 2009 (UTC)[reply]

I feared as much! Pdcook (talk) 19:29, 13 October 2009 (UTC)[reply]

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