Talk:Acute beryllium poisoning

Missing from article

One glaring omission is why Beryllium is poisonous. What's the mechanism of action; does it replace magnesium in the same way cadmium replaces zinc? Why is beryllium poisonous when boron, lithium, magnesium, and zinc aren't? Stonemason89 (talk) 15:57, 12 January 2011 (UTC)

From my related answer on RD/S: A 2006 review article (PMID 16697706) in Clinical Immunology suggested that particular MHC class II alleles (in HLA-DP) have negatively-charged glutamic acid residues capable of complexing beryllium, resulting in the broad activation of CD4+ T cells (reminiscent of the recent report in Science explaining the mechanisms of silver "allergy"). This is plausible though the phenotype is variable and it's likely to involve more factors; for example, a 2010 report PMID 20075058 suggests additional contribution of polymorphisms in CCR5, a chemokine receptor that has been shown to be important in T cell migration. The HLA-DP polymorphisms may provide the trigger, and the CCR5 polymorphisms may determine severity. -- Scray (talk) 14:42, 23 November 2012 (UTC)

I'll soon incorporate this into the article. -- Scray (talk) 04:22, 24 November 2012 (UTC)

addtitional sources

• Kriebel, David; Brain, Joseph D.; Sprince, Nancy L.; Kazemi, Homayoun (1988). "The Pulmonary Toxicity of Beryllium". American Review of Respiratory Disease. 137 (2): 464–473. doi:10.1164/ajrccm/137.2.464. ISSN 0003-0805.
• Sharma, Pragya; Johri, Sonia; Shukla, Sangeeta (2000). "Beryllium-induced toxicity and its prevention by treatment with chelating agents". Journal of Applied Toxicology. 20 (4): 313–318. doi:10.1002/1099-1263(200007/08)20:4<313::AID-JAT660>3.0.CO;2-J. ISSN 0260-437X.
• Lindenschmidt, R.C.; Sendelbach, L.E.; Witschi, H.P.; Price, D.J.; Fleming, J.; Joshi, J.G. (1986). "Ferritin and in vivo beryllium toxicity". Toxicology and Applied Pharmacology. 82 (2): 344–350. doi:10.1016/0041-008X(86)90211-5. ISSN 0041-008X.
• Cummings, B; Kaser, M R; Wiggins, G; Ord, M G; Stocken, L A (1982). "Beryllium toxicity. The selective inhibition of casein kinase 1". Biochemical Journal. 208 (1): 141–146. doi:10.1042/bj2080141. ISSN 0264-6021.
• VanORDSTRAND, H. S. (1945). "BERYLLIUM POISONING". Journal of the American Medical Association. 129 (16): 1084. doi:10.1001/jama.1945.02860500016005. ISSN 0002-9955.
• Strupp, C. (2010). "Beryllium Metal I. Experimental Results on Acute Oral Toxicity, Local Skin and Eye Effects, and Genotoxicity". Annals of Occupational Hygiene. 55 (1): 30–42. doi:10.1093/annhyg/meq071. ISSN 0003-4878.
• Strupp, C. (2010). "Beryllium Metal II. A Review of the Available Toxicity Data". Annals of Occupational Hygiene. 55 (1): 43–56. doi:10.1093/annhyg/meq073. ISSN 0003-4878.

- — Preceding unsigned comment added by Stone (talk • contribs) 08:33, 4 April 2016‎ (UTC)

Thanks for the citations but these are all very old or primary sources or both. Please read WP:MEDRS. If you don't understand it please ask. Jytdog (talk) 08:48, 4 April 2016 (UTC)

Thanks, the last one is a review, and if you find a book with better material than feel free to use it. --Stone (talk) 20:52, 4 April 2016 (UTC)

Yes it is! PMID 21196456. I will read that and add stuff based on it. Interesting stuff that it is saying! Need to consider. Jytdog (talk) 21:04, 4 April 2016 (UTC)

Ther must be a "normal" toxicology of oral or injected beryllum salts. What I found is 1980s and it sates that the toxicology is not well understood. PMC1153939. --21:08, 4 April 2016 (UTC)

I am not sure what you mean about "normal" tox. What do you mean? And this the source you mean there? Jytdog (talk) 21:11, 4 April 2016 (UTC)

All the beryllium toxicology is lung and skin contact things, either acute or longterm. Where is the data for the LD50 numbers oral and why is it only problematic if inhaled? There is little to nothing on oral and intravenous toxicology of beryllium salts, but this should also part of the toxicology. Inhaling is high risk, while eating it is low risk, this needs an explaination and there should be one in the literature. The ref I gave says that little is known, but this was back in the 1980s.--Stone (talk) 22:01, 4 April 2016 (UTC)

Ohby "normal" you meant oral i guess. it is my understanding that tox studies tend to focus on route of common exposure which is dermal or inhaled, so i don't reckon there would be much work done on oral... Jytdog (talk) 00:46, 5 April 2016 (UTC)