TSPAN6

TSPAN6
Identifiers
Aliases	TSPAN6, T245, TM4SF6, TSPAN-6, tetraspanin 6
External IDs	OMIM: 300191 MGI: 1926264 HomoloGene: 20700 GeneCards: TSPAN6
Gene location (Human) Chr. X chromosome (human) Band Xq22.1 Start 100,627,108 bp End 100,639,991 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X E3 Start 132,791,817 bp End 132,799,178 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm parotid gland bronchial epithelial cell tibia renal medulla oral cavity palpebral conjunctiva kidney tubule right uterine tube embryo Top expressed in saccule otic placode endocardial cushion atrioventricular valve medial ganglionic eminence molar abdominal wall neural tube seminiferous tubule maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signal transducer activity Cellular component integral component of membrane integral component of plasma membrane extracellular exosome membrane Biological process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of NIK/NF-kappaB signaling cell surface receptor signaling pathway negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7105 56496 Ensembl ENSG00000000003 ENSMUSG00000067377 UniProt O43657 O70401 RefSeq (mRNA) NM_001278740 NM_001278741 NM_001278742 NM_001278743 NM_003270 NM_019656 RefSeq (protein) NP_001265669 NP_001265670 NP_001265671 NP_001265672 NP_003261 n/a Location (UCSC) Chr X: 100.63 – 100.64 Mb Chr X: 132.79 – 132.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene.

Further reading

• Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
• Todd SC, Doctor VS, Levy S (1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim. Biophys. Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.