TSPAN4

TSPAN4
Identifiers
Aliases	TSPAN4, NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4, tetraspanin 4
External IDs	OMIM: 602644 MGI: 1928097 HomoloGene: 2453 GeneCards: TSPAN4
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.5 Start 842,812 bp End 867,116 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F5 Start 141,055,153 bp End 141,073,340 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right lung left uterine tube canal of the cervix subcutaneous adipose tissue upper lobe of left lung tibial nerve right lobe of thyroid gland left lobe of thyroid gland gastric mucosa Top expressed in calvaria internal carotid artery external carotid artery adrenal gland cerebellar cortex ankle renal corpuscle rib carotid body cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antigen binding integrin binding protein binding Cellular component integral component of membrane vesicle plasma membrane integral component of plasma membrane membrane focal adhesion Biological process cell surface receptor signaling pathway protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7106 64540 Ensembl ENSG00000214063 ENSMUSG00000025511 UniProt O14817 Q9DCK3 RefSeq (mRNA) NM_001025234 NM_001025235 NM_001025236 NM_001025237 NM_001025238 NM_001025239 NM_003271 NM_001252588 NM_053082 RefSeq (protein) NP_001020405 NP_001020406 NP_001020407 NP_001020408 NP_001020409 NP_001020410 NP_003262 NP_001239517 NP_444312 NP_001390284 NP_001390285 NP_001390286 NP_001390287 Location (UCSC) Chr 11: 0.84 – 0.87 Mb Chr 7: 141.06 – 141.07 Mb PubMed search
Wikidata
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Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.

Interactions

TSPAN4 has been shown to interact with CD9, ITGA6, CD29, CD49c and CD81.

Further reading

• Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
• Todd SC, Doctor VS, Levy S (1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim. Biophys. Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
• Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
• Yauch RL, Kazarov AR, Desai B, et al. (2000). "Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151". J. Biol. Chem. 275 (13): 9230–8. doi:10.1074/jbc.275.13.9230. PMID 10734060.
• Lozahic S, Christiansen D, Manié S, et al. (2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. Bibcode:2003Sci...302.1960C. doi:10.1126/science.1088821. PMID 14671302. S2CID 6682593.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.