TRPM6

TRPM6
Identifiers
Aliases	TRPM6, CHAK2, HMGX, HOMG, HOMG1, HSH, transient receptor potential cation channel subfamily M member 6
External IDs	OMIM: 607009 MGI: 2675603 HomoloGene: 9767 GeneCards: TRPM6
Gene location (Human) Chr. Chromosome 9 (human) Band 9q21.13 Start 74,722,495 bp End 74,888,094 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 B Start 18,727,347 bp End 18,869,875 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa rectum hair follicle duodenum corpus callosum blood retinal pigment epithelium bone marrow cells lower lobe of lung inferior ganglion of vagus nerve Top expressed in conjunctival fornix left colon spermatid right lung lobe seminiferous tubule oocyte secondary oocyte Paneth cell yolk sac blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding metal ion binding kinase activity protein serine/threonine kinase activity ion channel activity protein binding cation channel activity ATP binding calcium channel activity Cellular component integral component of membrane membrane plasma membrane brush border membrane apical plasma membrane Biological process phosphorylation metal ion transport cation transport ion transport protein tetramerization protein phosphorylation calcium ion transmembrane transport response to toxic substance calcium ion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140803 225997 Ensembl ENSG00000119121 ENSMUSG00000024727 UniProt Q9BX84 Q8CIR4 RefSeq (mRNA) NM_001177310 NM_001177311 NM_017662 NM_153417 RefSeq (protein) NP_001170781 NP_001170782 NP_060132 NP_700466 Location (UCSC) Chr 9: 74.72 – 74.89 Mb Chr 19: 18.73 – 18.87 Mb PubMed search
Wikidata
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TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.

See also

• TRPM
• Ruthenium red

Further reading

• Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. Vol. 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
• Chubanov V, Gudermann T, Schlingmann KP (2006). "Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis". Pflügers Arch. 451 (1): 228–34. doi:10.1007/s00424-005-1470-y. PMID 16075242. S2CID 6037803.
• Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
• Bödding M (2007). "TRPM6: A Janus-like protein". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. Vol. 179. pp. 299–311. doi:10.1007/978-3-540-34891-7_18. ISBN 978-3-540-34889-4. PMID 17217065.

External links

• TRPM6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.