TLL2

TLL2
Identifiers
Aliases	TLL2, tolloid like 2
External IDs	OMIM: 606743 MGI: 1346044 HomoloGene: 56545 GeneCards: TLL2
Gene location (Human) Chr. Chromosome 10 (human) Band 10q24.1 Start 96,364,608 bp End 96,513,926 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 C3 Start 41,071,192 bp End 41,195,274 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ventricle Brodmann area 23 right ventricle middle temporal gyrus prefrontal cortex atrium islet of Langerhans Brodmann area 9 striated muscle tissue inferior olivary nucleus Top expressed in esophagus stria vascularis mesencephalon ovary More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding zinc ion binding peptidase activity metalloendopeptidase activity hydrolase activity metallopeptidase activity metal ion binding serine-type endopeptidase activity Cellular component extracellular region Biological process multicellular organism development cell differentiation extracellular matrix disassembly negative regulation of skeletal muscle tissue growth proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7093 24087 Ensembl ENSG00000095587 ENSMUSG00000025013 UniProt Q9Y6L7 Q9WVM6 RefSeq (mRNA) NM_012465 NM_011904 RefSeq (protein) NP_036597 NP_036034 Location (UCSC) Chr 10: 96.36 – 96.51 Mb Chr 19: 41.07 – 41.2 Mb PubMed search
Wikidata
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Tolloid-like protein 2 is a protein that in humans is encoded by the TLL2 gene.

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Scott IC, Blitz IL, Pappano WN, et al. (1999). "Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis". Dev. Biol. 213 (2): 283–300. doi:10.1006/dbio.1999.9383. PMID 10479448.
• Reynolds SD, Zhang D, Puzas JE, et al. (2000). "Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues". Gene. 248 (1–2): 233–43. doi:10.1016/S0378-1119(00)00114-1. PMID 10806368.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Uzel MI, Scott IC, Babakhanlou-Chase H, et al. (2001). "Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures". J. Biol. Chem. 276 (25): 22537–43. doi:10.1074/jbc.M102352200. PMID 11313359.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.