t(11:14)

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Overview of some chromosomal translocations involved in different cancers, as well as implicated in some other conditions, e.g. schizophrenia,[1] with chromosomes arranged in standard karyogram order. t(11;14) is seen in center. Abbreviations:
ALL – Acute lymphoblastic leukemia
AML – Acute myeloid leukemia
CML – Chronic myelogenous leukemia
DFSP – Dermatofibrosarcoma protuberans

t(11;14) is a chromosomal translocation which essentially always involves the immunoglobulin heavy locus, also known as IGH in the q32 region of chromosome 14 , as well as cyclin D1 which is located in the q13 of chromosome 11 .[2] Specifically, the translocation is at t(11;14)(q13;q32).[3][4]

The translocation is mainly found in mantle cell lymphoma, but also in B-cell prolymphocytic leukemia, in plasma cell leukemia, in splenic lymphoma with villous lymphocytes, in chronic lymphocytic leukemia, and in multiple myeloma. All these diseases involve B-lineage lymphocytes.[2]

Prognosis

In multiple myeloma, t(11;14) is a neutral prognostic factor in general, but it may confer a worse prognosis for overall survival in African American people with multiple myeloma.[5]

References

  1. ^ Semple CA, Devon RS, Le Hellard S, Porteous DJ (April 2001). "Identification of genes from a schizophrenia-linked translocation breakpoint region". Genomics. 73 (1): 123–6. doi:10.1006/geno.2001.6516. PMID 11352574.
  2. ^ a b Jean-Loup Huret (1998-05-01). "t(11;14)(q13;q32) IGH/CCND1". Atlas Genet Cytogenet Oncol Haematol.
  3. ^ Li JY, Gaillard F, Moreau A, et al. (May 1999). "Detection of translocation t(11;14)(q13;q32) in mantle cell lymphoma by fluorescence in situ hybridization". Am. J. Pathol. 154 (5): 1449–52. doi:10.1016/S0002-9440(10)65399-0. PMC 1866594. PMID 10329598.
  4. ^ Barouk-Simonet E, Andrieux J, Copin MC, et al. (2002). "TPA stimulation culture for improved detection of t(11;14)(q13;q32) in mantle cell lymphoma". Ann. Genet. 45 (3): 165–8. doi:10.1016/S0003-3995(02)01122-X. PMID 12381451.
  5. ^ Gasparetto C, Jagannath S, Rifkin RM, Durie BGM, Narang M, Terebelo HR; et al. (2022). "Effect of t (11;14) Abnormality on Outcomes of Patients With Newly Diagnosed Multiple Myeloma in the Connect MM Registry". Clin Lymphoma Myeloma Leuk. 22 (3): 149–157. doi:10.1016/j.clml.2021.08.007. PMID 34588149.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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