Sulfadoxine

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Sulfadoxine
Sulfadoxine.svg
Sulfadoxine-3D-balls.png
Clinical data
AHFS/Drugs.comInternational Drug Names
ATCvet code
Identifiers
  • 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
ECHA InfoCard100.017.732 Edit this at Wikidata
Chemical and physical data
FormulaC12H14N4O4S
Molar mass310.33 g·mol−1
3D model (JSmol)
Melting point190 to 194 °C (374 to 381 °F)
  • COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N
 ☒NcheckY (what is this?)  (verify)

Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.[1]

It is also used to prevent malaria[2] but due to high levels of resistance, this use is becoming less common.[3]

It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[citation needed]

Mechanism of action

Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.

See also

References

  1. ^ Medical Treatment - Sulphadoxine and Pyrimethamine Archived 2007-12-28 at the Wayback Machine.
  2. ^ "WHO | Intermittent preventive treatment in pregnancy (IPTp)". Who.int. Retrieved 27 November 2021.
  3. ^ Matondo SI, Temba GS, Kavishe AA, et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania". Malar J. 13: 152. doi:10.1186/1475-2875-13-152. PMC 3998221. PMID 24751352.