Streptomycin-6-phosphatase

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streptomycin-6-phosphatase
Identifiers
EC no.3.1.3.39
CAS no.9055-33-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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The enzyme streptomycin-6-phosphatase (EC 3.1.3.39) catalyzes the reaction

streptomycin 6-phosphate + H2O streptomycin + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is streptomycin-6-phosphate phosphohydrolase. Other names in common use include streptomycin 6-phosphate phosphatase, streptomycin 6-phosphate phosphohydrolase, and streptomycin-6-P phosphohydrolase. This enzyme participates in streptomycin biosynthesis.

References

  • Walker JB, Skorvaga M (1973). "Streptomycin biosynthesis and metabolism. Phosphate transfer from dihydrostreptomycin 6-phosphate to inosamines, streptamine, and 2-deoxystreptamine". J. Biol. Chem. 248 (7): 2441–6. PMID 4121457.
  • Walker MS, Walker JB (1971). "Streptomycin biosynthesis. Separation and substrate specificities of phosphatases acting on guanidinodeoxy-scyllo-inositol phosphate and streptomycin-(streptidino)phosphate". J. Biol. Chem. 246 (22): 7034–40. PMID 4331203.