Sofituzumab vedotin

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Sofituzumab vedotin
Monoclonal antibody
Type?
SourceHumanized (from mouse)
Targetcarbohydrate antigen 125
Clinical data
Other namesDMUC5754A
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
Molar mass144.7 kg/mol

Sofituzumab vedotin (INN;[1] development code DMUC5754A) is a monoclonal antibody designed for the treatment of ovarian cancer.[2]

This drug was developed by Genentech/Roche.

Sofituzumab vedotin is an antibody-drug conjugate that targets MUC16, a protein that is overexpressed in several types of cancer including ovarian and pancreatic cancer. The conjugate consists of a human anti-nectin-4 antibody linked to the cytotoxic agent MMAE, which is released after internalization by the cancer cell. In addition to its direct cytotoxic effect, sofituzumab vedotin may also mediate antitumor activity through signal transduction inhibition, antibody-dependent cellular cytotoxicity, and complement-dependent cytotoxicity. Clinical trials have shown promising results in the treatment of ovarian and pancreatic cancer.[3]

References

  1. ^ World Health Organization (2013). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 110" (PDF). WHO Drug Information. 27 (4).
  2. ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Ralpancizumab, American Medical Association.
  3. ^ "Sofituzumab Vedotin Overview - Creative Biolabs". www.creativebiolabs.net. Retrieved 2023-03-04.