Sodium glycerophosphate

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Sodium glycerophosphate
Clinical data
Trade namesGlycophos
AHFS/Drugs.comProfessional Drug Facts
Pregnancy
category
Routes of
administration		Intravenous infusion
ATC code
Legal status
Legal status
  • AU: Unscheduled[2]
Identifiers
  • disodium 3-(phosphonooxy)propane-1,2-diol
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC3H7Na2O6P
Molar mass216.036 g·mol−1
3D model (JSmol)
Melting point98 to 100 °C (208 to 212 °F)
Solubility in watervery soluble
  • [Na+].[Na+].OCC(O)COP([O-])([O-])=O
  • InChI=1S/C3H9O6P.2Na/c4-1-3(5)2-9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;/q;2*+1/p-2
  • Key:GEKBIENFFVFKRG-UHFFFAOYSA-L
  • Key:OFNNKPAERNWEDD-UHFFFAOYSA-L

Sodium glycerophosphate, sold under the brand name Glycophos, is a medication used to supplement phosphate.[3][4] It is administered via intravenous infusion.[3][4]

Sodium glycerophosphate is an organic phosphate salt.[3][4]

It was approved for medical use in Australia in November 2019.[5][3][6]

It is an unapproved medication in the United States that was used as a substitute for inorganic phosphate during a drug shortage.[4]

Chemistry

The substance is a mixture of disodium glycerol 1- and 2-phosphates, which have different amounts of water of crystallization; the total amount is 5+1⁄2 H2O per glycerol phosphate molecule. It is a white to off-white powder which may or may not be crystalline, has no discernible odor and tastes salty. It melts at 98 to 100 °C (208 to 212 °F) and decomposes at 130 °C (266 °F). Aqueous solutions have a pH of about 9.5.[7]

References

  1. ^ "Glycophos APMDS". Therapeutic Goods Administration (TGA). 26 May 2022. Retrieved 10 March 2024.
  2. ^ "Australian Public Assessment Report for Sodium glycerophosphate (as hydrate)" (PDF). Therapeutic Goods Administration (TGA).
  3. ^ a b c d "ARTG Entry:312021 Glycophos Product Information" (PDF). Therapeutic Goods Administration (TGA). Retrieved 23 August 2020.
  4. ^ a b c d "Glycophos- sodium glycolate injection, solution". DailyMed. 16 January 2019. Retrieved 23 August 2020.
  5. ^ "Glycophos Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). Retrieved 23 August 2020.
  6. ^ "Summary for ARTG Entry:312021 Glycophos sodium glycerophosphate (as hydrate) 4.32 g/20 mL concentrated solution for injection ampoule". Therapeutic Goods Administration (TGA). Archived from the original on 18 April 2021. Retrieved 23 August 2020.
  7. ^ Hagers Handbuch der pharmazeutischen Praxis (in German). Vol. VI.A (4th ed.). Springer. 15 August 1977. pp. 91–92. ISBN 3-540-05123-6.


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