Sodium calcium edetate

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Sodium calcium edetate
Sodium calcium edetate.svg
Names
Trade namesCalcium disodium versenate, others
Other namesedetate calcium disodium, sodium calcium edetate
Clinical data
Drug classchelating agent
Pregnancy
category
  • US: B (No risk in non-human studies)
Routes of
use
IV, IM
Defined daily dosenot established[1]
External links
AHFS/Drugs.comMonograph
Chemical and physical data
FormulaC10H12CaN2Na2O8
Molar mass374.270 g·mol−1
3D model (JSmol)

Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning.[2] This includes short term and long term lead poisoning.[3] For lead encephalopathy it is typically used together with dimercaprol.[3] It does not appear to be useful for tetraethyllead toxicity.[3] It is given by slow injection into a vein or into a muscle.[2]

Common side effects include pain at the site of injection.[3] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[2] Benefits when needed in pregnancy are likely greater than the risks.[3] Sodium calcium edetate is in the chelating agent family of medication.[3] It is a salt of edetate with two sodium and one calcium atoms.[4] It works by binding a number of heavy metals which allows them to leave the body in the urine.[3]

Sodium calcium edetate came into medical use in the United States in 1953.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] In the United States a course of treatment costs 50 to 100 USD as of 2015.[6] Edetate disodium is a different formulation which does not have the same effects.[3]

Uses

Medical

Sodium calcium edetate's primarily use is to treat lead poisoning,[2] for which it is an alternative to succimer.[3] It is given by slow injection into a vein or into a muscle.[2]

For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.[3] It may also be used to treat plutonium poisoning.[7] It does not appear to be useful for poisoning by tetra-ethyl lead.[3]

Dosage

The defined daily dose is not established[1]

Chelation agent

Sodium calcium edetate is in the chelating agent family of medication.[3] It is a salt of edetate with two sodium and one calcium atoms.[8] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.[3]

Edetate disodium is a different formulation which does not have the same effects.[3]

Side effects

Common side effects include pain at the site of injection.[3] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[2] Benefits when needed in pregnancy are likely greater than the risks.[3]

History

Sodium calcium edetate came into medical use in the United States in 1953.[3] It is on the World Health Organization's List of Essential Medicines.[9] As of 2015 in the United States, a course of treatment costs US$50 to US$100.[6]

References

  1. 1.0 1.1 "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 13 September 2020.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. X. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 January 2017.
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
  4. Kasture, Dr A. V. (2008). Pharmaceutical Chemistry - I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 16 January 2017.
  5. "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
  6. 6.0 6.1 Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 471. ISBN 9781284057560.
  7. Flanagan, Robert; Jones, Alison; Maynard, Robert L. (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071. Archived from the original on 16 January 2017.
  8. Kasture, A.V., Dr. (2008). Pharmaceutical Chemistry. I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 16 January 2017.
  9. World Health Organization model list of essential medicines: 21st list 2019. Geneva,CH: World Health Organization. 2019. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

External links

Identifiers:
  • "Sodium calcium edetate". U.S. National Library of Medicine. Drug Information Portal. U.S. National Institutes of Health.