Sitagliptin/metformin

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Sitagliptin/metformin
Combination of
SitagliptinDipeptidyl peptidase-4 inhibitor
MetforminBiguanide
Names
Trade namesJanumet, Januet, others
Clinical data
Pregnancy
category
  • AU: C[1]
  • US: N (Not classified yet)[1]
Routes of
use		By mouth
External links
AHFS/Drugs.comProfessional Drug Facts
Legal
License data
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)

Sitagliptin/metformin, sold under the brand name Janumet among others, is a combination medication used to treat type 2 diabetes.[2] It may be used in those whose blood sugar is not controlled with metformin and a sulfonylurea.[2][3] It is taken by mouth.[2]

Common side effects include diarrhea, headache, and upper respiratory tract infections.[1] Serious side effects may include lactic acidosis, pancreatitis, low blood sugar, heart failure, joint pain, and allergic reactions.[1] It has not been properly studied in people who are pregnant or breastfeeding.[4] It contains sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin (a biguanide).[1]

The combination was approved for medical use in the United States in 2007.[1] A month supply in the United Kingdom costs the NHS about 33.26 £ as of 2019.[2] In the United States the wholesale cost of this amount is about US$433.[5] In 2017, it was the 139th most commonly prescribed medication in the United States, with more than four million prescriptions.[6][7]

Society and culture

Brand names

As of 2018, the combination was marketed under several brand names, including Efficib, Janmet, Januet, Janumet, Jznumet, Ristaben Met, Ristfor, Siglimet, Sitamet, Sitar-M, Sliptin-M, Treviamet, and Velmetia.[8]

Cost

  • Metformin/Sitagliptin costs (US)

    Metformin/Sitagliptin costs (US)

  • Metformin/Sitagliptin prescriptions (US)

    Metformin/Sitagliptin prescriptions (US)

A month supply in the United Kingdom costs the NHS about 33.26 £ as of 2019.[2] In the United States the wholesale cost of this amount is about US$433.[5] In Denmark 100 tablets (each 1,000 mg) cost over the counter in a pharmacy DKK 62.60 = US$9.40 = £7.50, thus a month supply in Denmark costs DKK 37.50 = US$5.70 = £4.50. The pharmacy buys wholesale at DKK 33.83 = US$5.11 = £4.10.[9]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "Janumet - FDA prescribing information, side effects and uses". Drugs.com. Archived from the original on 19 April 2019. Retrieved 19 April 2019.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 682. ISBN 9780857113382.
  3. ↑ Hayes J, Anderson R, Stephens JW (2016). "Sitagliptin/metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy". Drug Design, Development and Therapy. 10: 2263–70. doi:10.2147/DDDT.S93076. PMC 4958358. PMID 27486305.
  4. ↑ "Metformin / sitagliptin Use During Pregnancy". Drugs.com. Archived from the original on 19 April 2019. Retrieved 19 April 2019.
  5. ↑ 5.0 5.1 "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
  6. ↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
  7. ↑ "Metformin Hydrochloride; Sitagliptin Phosphate - Drug Usage Statistics". ClinCalc. Archived from the original on 9 July 2018. Retrieved 11 April 2020.
  8. ↑ "International brands for Sitagliptin/metformin". Drugs.com. Archived from the original on 23 August 2019. Retrieved 3 September 2018.
  9. ↑ "Medicinpriser". Medicinpriser (in dansk). Archived from the original on 15 May 2020. Retrieved 17 June 2019.

External links

Identifiers:
  • "Sitagliptin". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 2020-07-18. Retrieved 2020-04-15.
  • "Metformin". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 2016-05-17. Retrieved 2020-04-15.


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