Serostatus

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p24 antigen can be detected in the blood earlier than antibodies, usually within 2-4 weeks after infection[1]

Serostatus refers to the presence or absence of a serological marker in the blood. The presence of detectable levels of a specific marker within the serum is considered seropositivity, while the absence of such levels is considered seronegativity.

HIV/AIDS

The term serostatus is commonly used in HIV/AIDS prevention efforts. In the late 20th and early 21st centuries, social advocacy has emphasized the importance of learning one's HIV/AIDS serostatus in an effort to curtail the spread of the disease.[2]

Autoimmune disease

Researchers have investigated the effects of autoantibody serostatus on autoimmune disease presentation.[3][4][5] Study of seronegative patient populations has led to the identification of additional autoantibodies that could potentially help with diagnosis.[6][7]

See also

References

  1. Gray, Eleanor R; Bain, Robert; Varsaneux, Olivia; Peeling, Rosanna W; Stevens, Molly M; McKendry, Rachel A (24 September 2018). "p24 revisited: A landscape review of antigen detection for early HIV diagnosis". AIDS (London, England). 32 (15): 2089–2102. doi:10.1097/QAD.0000000000001982. ISSN 0269-9370. Archived from the original on 29 May 2024. Retrieved 27 September 2024.
  2. Janssen RS, Holtgrave DR, Valdiserri RO, et al. (July 2001). "The Serostatus Approach to Fighting the HIV Epidemic: prevention strategies for infected individuals". American Journal of Public Health. American Public Health Association. 91 (7): 1019–1024. doi:10.2105/AJPH.91.7.1019. ISSN 1541-0048. PMC 1446705. PMID 11441723.
  3. Jarius S, Ruprecht K, Wildemann B, et al. (January 2012). "Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients". Journal of Neuroinflammation. BioMed Central. 9 (1): 14. doi:10.1186/1742-2094-9-14. PMC 3283476. PMID 22260418.
  4. Ajeganova S, Huizinga TW (November 2014). "Rheumatoid arthritis: Seronegative and seropositive RA: alike but different?". Nature Reviews Rheumatology. Nature Publishing Group. 11 (1): 8–9. doi:10.1038/nrrheum.2014.194. ISSN 1759-4804. PMID 25403158. S2CID 1405551.
  5. Balasubramanian G, Sugumar A, Smyrk TC, et al. (2012). "Demystifying seronegative autoimmune pancreatitis". Pancreatology. Elsevier. 12 (4): 289–294. doi:10.1016/j.pan.2012.05.003. PMID 22898628.
  6. Somers K, Geusens P, Elewaut D, et al. (February 2011). "Novel autoantibody markers for early and seronegative rheumatoid arthritis". Journal of Autoimmunity. Elsevier. 36 (1): 33–46. doi:10.1016/j.jaut.2010.10.003. ISSN 0896-8411. PMID 21071175.
  7. Pevzner A, Schoser B, Peters K, et al. (August 2011). "Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis" (PDF). Journal of Neurology. Springer-Verlag. 259 (3): 427–435. doi:10.1007/s00415-011-6194-7. ISSN 1432-1459. PMID 21814823. S2CID 13125248.