Solute carrier organic anion transporter family member 2A1

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SLCO2A1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSLCO2A1, MATR1, OATP2A1, PGT, PHOAR2, SLC21A2, solute carrier organic anion transporter family member 2A1, PHOAD
External IDsOMIM: 601460 MGI: 1346021 HomoloGene: 38077 GeneCards: SLCO2A1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005630

NM_033314

RefSeq (protein)

NP_005621

NP_201571

Location (UCSC)Chr 3: 133.93 – 134.05 MbChr 9: 102.87 – 102.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier organic anion transporter family member 2A1, also known as the prostaglandin transporter (PGT), is a protein that in humans is encoded by the SLCO2A1 gene.[5]

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.[5]

Clinical relevance

Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy,[6] specific form of chronic enteropathy.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174640 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032548 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Solute carrier organic anion transporter family, member 2A1". Retrieved 2011-12-30.
  6. ^ Zhang Z, Xia W, He J, Zhang Z, Ke Y, Yue H, Wang C, Zhang H, Gu J, Hu W, Fu W, Hu Y, Li M, Liu Y (January 2012). "Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy". American Journal of Human Genetics. 90 (1): 125–32. doi:10.1016/j.ajhg.2011.11.019. PMC 3257902. PMID 22197487.

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: Q92959 (Solute carrier organic anion transporter family member 2A1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.