SLC8B1

SLC8B1
Identifiers
Aliases	SLC8B1, NCKX6, NCLX, SLC24A6, solute carrier family 8 member B1
External IDs	OMIM: 609841 MGI: 2180781 HomoloGene: 41602 GeneCards: SLC8B1
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.13 Start 113,298,759 bp End 113,359,493 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 120,649,233 bp End 120,672,089 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland spleen sural nerve blood canal of the cervix body of pancreas upper lobe of left lung minor salivary glands gastric mucosa monocyte Top expressed in left lobe of liver lip yolk sac left colon subcutaneous adipose tissue spleen morula ankle white adipose tissue upper arm More reference expression data BioGPS n/a
Gene ontology Molecular function protein homodimerization activity identical protein binding antiporter activity calcium:cation antiporter activity calcium:sodium antiporter activity calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential Cellular component integral component of membrane membrane plasma membrane mitochondrial crista mitochondrion integral component of mitochondrial membrane sarcolemma mitochondrial inner membrane Biological process sodium ion transmembrane transport regulation of cytosolic calcium ion concentration glucose homeostasis response to stimulus regulation of insulin secretion sodium ion transport ion transport calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential calcium ion transport transmembrane transport mitochondrial calcium ion transmembrane transport mitochondrial calcium ion homeostasis calcium export from the mitochondrion regulation of lymphocyte chemotaxis regulation of store-operated calcium entry Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80024 170756 Ensembl ENSG00000089060 ENSMUSG00000032754 UniProt Q6J4K2 Q925Q3 RefSeq (mRNA) NM_024959 NM_001330466 NM_001358345 NM_001177594 NM_001177595 NM_133221 RefSeq (protein) NP_001317395 NP_079235 NP_001345274 NP_001171065 NP_001171066 NP_573484 Location (UCSC) Chr 12: 113.3 – 113.36 Mb Chr 5: 120.65 – 120.67 Mb PubMed search
Wikidata
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Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 is a protein that in humans is encoded by the SLC8B1 gene.

Function

SLC24A6 belongs to a family of Potassium-dependent sodium-calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion.

Further reading

• Boyman L, Williams GS, Khananshvili D, Sekler I, Lederer WJ (June 2013). "NCLX: the mitochondrial sodium calcium exchanger". Journal of Molecular and Cellular Cardiology. 59: 205–13. doi:10.1016/j.yjmcc.2013.03.012. PMC 3951392. PMID 23538132.
• Palty R, Ohana E, Hershfinkel M, Volokita M, Elgazar V, Beharier O, Silverman WF, Argaman M, Sekler I (June 2004). "Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger". The Journal of Biological Chemistry. 279 (24): 25234–40. doi:10.1074/jbc.M401229200. PMID 15060069.
• Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Tiwari HK, Tsai MY, Hopkins PN, Borecki IB, Ordovas JM, Arnett DK (October 2013). "Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network". Nutrition, Metabolism, and Cardiovascular Diseases. 23 (10): 987–94. doi:10.1016/j.numecd.2012.07.010. PMC 3578131. PMID 23149075.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.