Protein-coding gene in the species Homo sapiens
Serpin peptidase inhibitor, clade B (ovalbumin), member 10 is a protein that in humans is encoded by the SERPINB10 gene .[5]
Function The superfamily of high molecular weight serine proteinase inhibitors (serpins ) regulate a diverse set of intracellular and extracellular processes such as complement activation , fibrinolysis , coagulation , cellular differentiation , tumor suppression, apoptosis , and cell migration . Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices .[6] serpin PI1 , is characterized by a high degree of homology to chicken ovalbumin , lack of N- and C-terminal extensions, absence of a signal peptide , and a serine rather than an asparagine residue at the penultimate position.[7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000242550 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000092572 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: Serpin peptidase inhibitor, clade B (ovalbumin), member 10" .^ Huber R, Carrell RW (November 1989). "Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins". Biochemistry . 28 (23): 8951–66. doi :10.1021/bi00449a001 . PMID 2690952 . ^ * Bartuski AJ, Kamachi Y, Schick C, Overhauser J, Silverman GA (August 1997). "Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3". Genomics . 43 (3): 321–8. doi :10.1006/geno.1997.4827 . PMID 9268635 .
Further reading
Chuang TL, Schleef RR (April 1999). "Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10" . The Journal of Biological Chemistry . 274 (16): 11194–8. doi :10.1074/jbc.274.16.11194 PMID 10196205 . Lindskog C, Korsgren O, Pontén F, Eriksson JW, Johansson L, Danielsson A (May 2012). "Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates". Journal of Proteomics . 75 (9): 2611–20. doi :10.1016/j.jprot.2012.03.008 . PMID 22465717 . Schleef RR, Chuang TL (August 2000). "Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes" . The Journal of Biological Chemistry . 275 (34): 26385–9. doi :10.1074/jbc.C000389200 PMID 10871600 . Shioji G, Ezura Y, Nakajima T, Ohgaki K, Fujiwara H, Kubota Y, Ichikawa T, Inoue K, Shuin T, Habuchi T, Ogawa O, Nishimura T, Emi M (2005). "Nucleotide variations in genes encoding plasminogen activator inhibitor-2 and serine proteinase inhibitor B10 associated with prostate cancer" . Journal of Human Genetics . 50 (10): 507–15. doi :10.1007/s10038-005-0285-1 PMID 16172807 . Riewald M, Schleef RR (November 1995). "Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow" . The Journal of Biological Chemistry . 270 (45): 26754–7. doi :10.1074/jbc.270.45.26754 PMID 7592909 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
