SCUBE1

SCUBE1
Identifiers
Aliases	SCUBE1, signal peptide, CUB domain and EGF like domain containing 1
External IDs	OMIM: 611746 MGI: 1890616 HomoloGene: 11224 GeneCards: SCUBE1
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.2 Start 43,197,280 bp End 43,343,372 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 83,489,200 bp End 83,609,222 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa tibia tibial nerve sural nerve ganglionic eminence right lung vena cava synovial membrane upper lobe of left lung right adrenal gland Top expressed in habenula visual cortex superior frontal gyrus third ventricle urethra female urethra male urethra infundibular recess neural tube abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding identical protein binding protein heterodimerization activity Cellular component extracellular region cell surface extrinsic component of plasma membrane membrane external side of plasma membrane extracellular space plasma membrane Biological process endothelial cell differentiation blood coagulation inflammatory response protein homooligomerization post-embryonic development adult heart development signal transduction cell differentiation positive regulation of smoothened signaling pathway extracellular matrix disassembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80274 64706 Ensembl ENSG00000159307 ENSMUSG00000016763 UniProt Q8IWY4 Q6NZL8 RefSeq (mRNA) NM_173050 NM_001271472 NM_001271473 NM_022723 RefSeq (protein) NP_766638 NP_766638.2 NP_001258401 NP_001258402 NP_073560 Location (UCSC) Chr 22: 43.2 – 43.34 Mb Chr 15: 83.49 – 83.61 Mb PubMed search
Wikidata
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Signal peptide, CUB domain and EGF like domain containing 1 is a protein that in humans is encoded by the SCUBE1 gene.

Function

This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology.

Further reading

• Yang RB, Ng CK, Wasserman SM, Colman SD, Shenoy S, Mehraban F, Komuves LG, Tomlinson JE, Topper JN (2002). "Identification of a novel family of cell-surface proteins expressed in human vascular endothelium". J. Biol. Chem. 277 (48): 46364–73. doi:10.1074/jbc.M207410200. PMID 12270931.
• Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, Hudson T, Gladman D, Clarke AE, Pope JE, Peschken C, Smith CD, Hanly J, Rich E, Boire G, Barr SG, Zummer M, Fortin PR, Wither J, Rioux JD (2011). "A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles". Genes Immun. 12 (1): 51–8. doi:10.1038/gene.2010.47. PMID 20962850.
• Ulusoy S, Ozkan G, Menteşe A, Yavuz A, Karahan SC, Sümer AU (2012). "Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level". Clin. Biochem. 45 (16–17): 1444–9. doi:10.1016/j.clinbiochem.2012.07.103. PMID 22874483.
• Orr B, Grace OC, Brown P, Riddick AC, Stewart GD, Franco OE, Hayward SW, Thomson AA (2013). "Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1". Dis. Models Mech. 6 (2): 530–6. doi:10.1242/dmm.010355. PMC 3597035. PMID 23136397.
• Mentese A, Fidan E, Sumer AU, Karahan SC, Sonmez M, Altay DU, Kavgaci H, Alver A (2012). "Is SCUBE 1 a new biomarker for gastric cancer?". Cancer Biomark. 11 (5): 191–5. doi:10.3233/CBM-2012-00285. PMID 23220851.
• Menteşe A, Yilmaz G, Sümer A, Arslan M, Karahan SC, Köksal I (2013). "The diagnostic and prognostic significance of SCUBE1 levels in Crimean-Congo hemorrhagic fever". Int. J. Infect. Dis. 17 (11): e1042–5. doi:10.1016/j.ijid.2013.03.014. PMID 23632301.
• Topcu TO, Kavgaci H, Ozdemir F, Aksoy A, Erdem D, Mentese A, Yaman H, Tufan G, Orem A, Aydin F (2015). "Elevated Serum Levels of SCUBE1, a Marker for Coagulation, in Patients with Breast Cancer". Tohoku J. Exp. Med. 237 (2): 127–32. doi:10.1620/tjem.237.127. PMID 26438214.
• Liao WJ, Tsao KC, Yang RB (2016). "Electrostatics and N-glycan-mediated membrane tethering of SCUBE1 is critical for promoting bone morphogenetic protein signalling". Biochem. J. 473 (5): 661–72. doi:10.1042/BJ20151041. PMID 26699903. S2CID 20555581.
• Chen QH, Lin D, Zhou J, Deng G (2016). "Role of signal peptide-Cub-Egf domain-containing protein-1 in serum as a predictive biomarker of outcome after severe traumatic brain injury". Clin. Chim. Acta. 456: 63–6. doi:10.1016/j.cca.2016.02.021. PMID 26940951.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.